Mouse Genome Informatics
hm1
     Hoxdtm3Ddu/Hoxdtm3Ddu
involves: 129S2/SvPas * C57BL/6 * SJL
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:47900 )
• no obvious phenotype, no defect detected in reproductive or skeletal systems


Mouse Genome Informatics
cx2
     Hoxa11tm1Ssp/Hoxa11+
Hoxdtm3Ddu/Hoxd+
involves: 129S2/SvPas * C57BL/6 * CF-1 * SJL
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
skeleton
skeleton phenotype ( J:47900 )
N
• normal morphology of the ulna, radius, tibia, and fibula (J:47900)


Mouse Genome Informatics
cx3
     Hoxa11tm1Ssp/Hoxa11+
Hoxdtm3Ddu/Hoxdtm3Ddu
involves: 129S2/SvPas * C57BL/6 * CF-1 * SJL
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
limbs/digits/tail
abnormal fibula morphology ( J:47900 )
• lack of distal fusion of tibia and fibula
abnormal tibia morphology ( J:47900 )
• lack of distal fusion of tibia and fibula

skeleton
abnormal fibula morphology ( J:47900 )
• lack of distal fusion of tibia and fibula
abnormal tibia morphology ( J:47900 )
• lack of distal fusion of tibia and fibula


Mouse Genome Informatics
cx4
     Hoxa11tm1Ssp/Hoxa11tm1Ssp
Hoxdtm3Ddu/Hoxdtm3Ddu
involves: 129S2/SvPas * C57BL/6 * CF-1 * SJL
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
limbs/digits/tail
increased diameter of radius ( J:47900 )
• thickening of radius
increased diameter of ulna ( J:47900 )
• thickening of ulna
abnormal fibula morphology ( J:47900 )
• lack of distal fusion of tibia and fibula
increased diameter of fibula ( J:47900 )
• thickening of fibula
abnormal tibia morphology ( J:47900 )
• lack of distal fusion of tibia and fibula
increased diameter of tibia ( J:47900 )
• thickening of tibia

skeleton
increased diameter of radius ( J:47900 )
• thickening of radius
increased diameter of ulna ( J:47900 )
• thickening of ulna
abnormal fibula morphology ( J:47900 )
• lack of distal fusion of tibia and fibula
increased diameter of fibula ( J:47900 )
• thickening of fibula
abnormal tibia morphology ( J:47900 )
• lack of distal fusion of tibia and fibula
increased diameter of tibia ( J:47900 )
• thickening of tibia


Mouse Genome Informatics
cx5
     Del(2Hoxd11-Hoxd13)29Ddu/Hoxdtm3Ddu
involves: 129S2/SvPas * C57BL/6 * SJL
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
limbs/digits/tail
abnormal digit morphology ( J:47900 )
• reductions in size of digits II and V