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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hoxdtm3Ddu
targeted mutation 3, Denis Duboule
MGI:1857854
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hoxdtm3Ddu/Hoxdtm3Ddu involves: 129S2/SvPas * C57BL/6 * SJL MGI:2178144
cx2
 		Hoxa11tm1Ssp/Hoxa11+
Hoxdtm3Ddu/Hoxd+ 		involves: 129S2/SvPas * C57BL/6 * CF-1 * SJL MGI:2178137
cx3
 		Hoxa11tm1Ssp/Hoxa11+
Hoxdtm3Ddu/Hoxdtm3Ddu 		involves: 129S2/SvPas * C57BL/6 * CF-1 * SJL MGI:2178138
cx4
 		Hoxa11tm1Ssp/Hoxa11tm1Ssp
Hoxdtm3Ddu/Hoxdtm3Ddu 		involves: 129S2/SvPas * C57BL/6 * CF-1 * SJL MGI:2178140
cx5
 		Del(2Hoxd11-Hoxd13)29Ddu/Hoxdtm3Ddu involves: 129S2/SvPas * C57BL/6 * SJL MGI:2178141


Genotype
MGI:2178144
hm1
Allelic
Composition		 Hoxdtm3Ddu/Hoxdtm3Ddu
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:47900 )
• no obvious phenotype, no defect detected in reproductive or skeletal systems




Genotype
MGI:2178137
cx2
Allelic
Composition		 Hoxa11tm1Ssp/Hoxa11+
Hoxdtm3Ddu/Hoxd+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CF-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11tm1Ssp mutation (0 available); any Hoxa11 mutation (11 available)
Hoxdtm3Ddu mutation (0 available); any Hoxd mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:47900 )
N
• normal morphology of the ulna, radius, tibia, and fibula




Genotype
MGI:2178138
cx3
Allelic
Composition		 Hoxa11tm1Ssp/Hoxa11+
Hoxdtm3Ddu/Hoxdtm3Ddu
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CF-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11tm1Ssp mutation (0 available); any Hoxa11 mutation (11 available)
Hoxdtm3Ddu mutation (0 available); any Hoxd mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal fibula morphology ( J:47900 )
• lack of distal fusion of tibia and fibula
abnormal tibia morphology ( J:47900 )
• lack of distal fusion of tibia and fibula

skeleton
abnormal fibula morphology ( J:47900 )
• lack of distal fusion of tibia and fibula
abnormal tibia morphology ( J:47900 )
• lack of distal fusion of tibia and fibula




Genotype
MGI:2178140
cx4
Allelic
Composition		 Hoxa11tm1Ssp/Hoxa11tm1Ssp
Hoxdtm3Ddu/Hoxdtm3Ddu
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CF-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11tm1Ssp mutation (0 available); any Hoxa11 mutation (11 available)
Hoxdtm3Ddu mutation (0 available); any Hoxd mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
increased diameter of radius ( J:47900 )
• thickening of radius
increased diameter of ulna ( J:47900 )
• thickening of ulna
abnormal fibula morphology ( J:47900 )
• lack of distal fusion of tibia and fibula
increased diameter of fibula ( J:47900 )
• thickening of fibula
abnormal tibia morphology ( J:47900 )
• lack of distal fusion of tibia and fibula
increased diameter of tibia ( J:47900 )
• thickening of tibia

skeleton
increased diameter of radius ( J:47900 )
• thickening of radius
increased diameter of ulna ( J:47900 )
• thickening of ulna
abnormal fibula morphology ( J:47900 )
• lack of distal fusion of tibia and fibula
increased diameter of fibula ( J:47900 )
• thickening of fibula
abnormal tibia morphology ( J:47900 )
• lack of distal fusion of tibia and fibula
increased diameter of tibia ( J:47900 )
• thickening of tibia




Genotype
MGI:2178141
cx5
Allelic
Composition		 Del(2Hoxd11-Hoxd13)29Ddu/Hoxdtm3Ddu
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd11-Hoxd13)29Ddu mutation (2 available); any Del(2Hoxd11-Hoxd13)29Ddu mutation (2 available)
Hoxdtm3Ddu mutation (0 available); any Hoxd mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal digit morphology ( J:47900 )
• reductions in size of digits II and V




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory