Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm1Hfu mutation
(2 available);
any
Nrp1 mutation
(81 available)
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mortality/aging
cardiovascular system
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• defects as previously reported for mutations of this locus are observed
• however, mostly normal blood vessel network formation occurs in both yolk sac and embryo at E10
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nervous system
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• growth cone collapse of dorsal root ganglion and sympathetic ganglion axons in response to Sema3A was completely abolished
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• ophthalmic nerve fibers overshot their peripheral target fields
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• spinal nerve fibers overshot toward the opposite side of embryos after crossing the dorsal midline
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cellular
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• growth cone collapse of dorsal root ganglion and sympathetic ganglion axons in response to Sema3A was completely abolished
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm1Hfu mutation
(2 available);
any
Nrp1 mutation
(81 available)
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mortality/aging
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• by 13.5 dpc, most mutant embryos had died, but a few embryos with severe edema were still alive
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cardiovascular system
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• at E10.5 segements of the dorsal aorta are regressed
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• at E9.5 all embryos (N = 5) exhibited severe regression of the arch artery system (arch arteries 1 - 3 are normally bilaterally symmetrical at this time)
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• at E10.5 the arch arteries 1 and 2 often persisted
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• at E10.5, 15 out of 22 embryos lack the right and left arch arteries 4
• at E 12.5 the left arch artery 4, which normally forms the arch of the aorta is absent and the arch of the aorta forms on the right side (15 out of 21)
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• at E10.5 the arch arteries 1 and 2 often persisted
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• at E10.5, all embryos (N = 22) lack the right and left arch arteries 6
• at E12.5 all embryos (N = 21) lack the left arch artery 6
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• at E10.5, some embryos missing arch artery 4 also lack the arch artery 3 on either side
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• the distal end of the pulmonary channel merges with the aortic arch
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• at E12.5 the left subclavian artery arises from the right sided arch of the aorta
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• right arotic arch is observed in some mutants
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• observed in some mutants
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• capillary invasion is absent from the central nervous system of mutants at E10.5
• at E12.5 little vascularization is seen in the neocortex, dorsal part of the midbrain, spinal cord, and sensory ganglia
• at E12.5 abnormal capillaries, that are of large caliber, with few branches and often broken into small spherical segments, are present in the diencephalon, ventral midbrain, hindbrain, and ventral spinal cord
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• at E12.5 the yolk sac of mutants is as well vascularized as that of wild-types however the vascular networks are abnormal
• the large vessels meander and are often divided into small vessels that anastomose
• capillary networks in the yolk sac are sparse
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• at E12.5 seperation of the truncus arteriosus is incomplete (5 out of 6)
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embryo
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• at E9.5 all embryos (N = 5) exhibited severe regression of the arch artery system (arch arteries 1 - 3 are normally bilaterally symmetrical at this time)
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• at E10.5 the arch arteries 1 and 2 often persisted
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• at E10.5, 15 out of 22 embryos lack the right and left arch arteries 4
• at E 12.5 the left arch artery 4, which normally forms the arch of the aorta is absent and the arch of the aorta forms on the right side (15 out of 21)
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• at E10.5 the arch arteries 1 and 2 often persisted
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• at E10.5, all embryos (N = 22) lack the right and left arch arteries 6
• at E12.5 all embryos (N = 21) lack the left arch artery 6
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• at E10.5, some embryos missing arch artery 4 also lack the arch artery 3 on either side
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• at E12.5 the yolk sac of mutants is as well vascularized as that of wild-types however the vascular networks are abnormal
• the large vessels meander and are often divided into small vessels that anastomose
• capillary networks in the yolk sac are sparse
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craniofacial
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• at E9.5 all embryos (N = 5) exhibited severe regression of the arch artery system (arch arteries 1 - 3 are normally bilaterally symmetrical at this time)
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• at E10.5 the arch arteries 1 and 2 often persisted
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• at E10.5, 15 out of 22 embryos lack the right and left arch arteries 4
• at E 12.5 the left arch artery 4, which normally forms the arch of the aorta is absent and the arch of the aorta forms on the right side (15 out of 21)
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• at E10.5 the arch arteries 1 and 2 often persisted
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• at E10.5, all embryos (N = 22) lack the right and left arch arteries 6
• at E12.5 all embryos (N = 21) lack the left arch artery 6
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• at E10.5, some embryos missing arch artery 4 also lack the arch artery 3 on either side
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm1Hfu mutation
(2 available);
any
Nrp1 mutation
(81 available)
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nervous system
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• normal numbers of gonadotropin-releasing hormone neurons
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrp1tm1Hfu mutation
(2 available);
any
Nrp1 mutation
(81 available)
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nervous system
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• delayed tangential somata migration of facial branchiomotor neurons that resulted in the separation of the migratory stream into several distinct streams on the ventricular side of the hindbrain
• facial branchiomotor neuron somata emerged on the pial side in an ectopic anterior location during radial migration
• migration defects are not due to abnormal hindbrain segmentation, vascular defects in the hindbrain or axon guidance defects in the periphery
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• nuclei on the pial side were elongated or dumbbell-shaped and in severe cases, the entire nucleus was shifted anteriorly
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• defasciculated facial nerve
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• defasciculated trigeminal nerve branches
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cellular
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• delayed tangential somata migration of facial branchiomotor neurons that resulted in the separation of the migratory stream into several distinct streams on the ventricular side of the hindbrain
• facial branchiomotor neuron somata emerged on the pial side in an ectopic anterior location during radial migration
• migration defects are not due to abnormal hindbrain segmentation, vascular defects in the hindbrain or axon guidance defects in the periphery
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nervous system
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• reduced gonadotropin-releasing hormone neurons
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cardiovascular system
mortality/aging
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• embryos die at E10-10.5, showing longer survival thah double homozygous embryos
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embryo
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• yolk sacs are of normal size, but lack larger collecting vessels and contain irregular and less dense capillary networks
• vasulature of yolk sac at E10 is characterized by vessel heterogeneity, disorganization, and immaturity
• arterial and venous branching is not seen in yolk sacs at E10
• thickened blood vessels, lack of capillaries, and large avascular spaces between blood vessels are observed, with occasional dead-ended sprouts not connected to other sprouts
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• much smaller than littermates; length of embryo in yolk sac is ~50% of control embryo length
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growth/size/body
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• much smaller than littermates; length of embryo in yolk sac is ~50% of control embryo length
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cardiovascular system
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• avascular regions, vessel size heterogeneity, and thickened blood vessels are observed
• outflow tract formation is abnormal
• blood vessel density in head region is slightly higher than in Npr1tm1Hfu/Npr1+; Npr2tm1Mkl /Npr2tm1Mkl embryos
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• abnormal formation of dorsal aorta is observed
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• yolk sacs are of normal size, but lack larger collecting vessels and contain irregular and less dense capillary networks
• vasulature of yolk sac at E10 is characterized by vessel heterogeneity, disorganization, and immaturity
• arterial and venous branching is not seen in yolk sacs at E10
• thickened blood vessels, lack of capillaries, and large avascular spaces between blood vessels are observed, with occasional dead-ended sprouts not connected to other sprouts
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• multiple hemorrhages are observed in embryos at E10
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mortality/aging
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• embryos die at E10-10.5, showing longer survival thah double homozygous embryos
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embryo
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• yolk sacs are of normal size, but lack larger collecting vessels and contain irregular and less dense capillary networks
• vasulature of yolk sac at E10 is characterized by vessel heterogeneity, disorganization, and immaturity
• thickened blood vessels, lack of capillaries, and large avascular spaces between blood vessels are observed, with occasional dead-ended sprouts not connected to other sprouts
• arterial and venous branching is not seen in yolk sacs at E10
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cardiovascular system
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• embryos show severe vascular impairment at E10
• blood vessels are disorganized, heterogeneous in size, and some show thickening
• blood vessel density is low in the head region, with avascular regions in head and trunk
• small vessel sprouting is seen, but is unconnected to other sprouts and no capillary plexus is formed
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• dorsal aorta is poorly formed, and outflow tract is undetectable
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• yolk sacs are of normal size, but lack larger collecting vessels and contain irregular and less dense capillary networks
• vasulature of yolk sac at E10 is characterized by vessel heterogeneity, disorganization, and immaturity
• thickened blood vessels, lack of capillaries, and large avascular spaces between blood vessels are observed, with occasional dead-ended sprouts not connected to other sprouts
• arterial and venous branching is not seen in yolk sacs at E10
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• multiple hemorrhages are observed in embryos at E10
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Analysis Tools