Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a1r mutation
(2 available);
any
Slc11a1 mutation
(40 available)
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immune system
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• increased resistance to mycobacterial infection during the early but not the late phase of acquired immunity
• spleen bacterial loads in mice infected with 103 Salmonella CFUs increased steadily from day 1 until day 7, then declined sharply by day 21, and were almost undetectable by day 42 postinfection
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a1r mutation
(2 available);
any
Slc11a1 mutation
(40 available)
|
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immune system
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• increased resistance to mycobacterial infection during the early but not the late phase of acquired immunity
• little or no bacterial proliferation in the spleen at any time following BCG inoculation
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a1r mutation
(2 available);
any
Slc11a1 mutation
(40 available)
Slc11a1s mutation
(0 available);
any
Slc11a1 mutation
(40 available)
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immune system
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• little or no bacterial proliferation was observed in the spleen at any time following BCG inoculation
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a1r mutation
(2 available);
any
Slc11a1 mutation
(40 available)
Slc11a1s mutation
(0 available);
any
Slc11a1 mutation
(40 available)
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immune system
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• 42 days after IV injection of 103 Salmonella enteritidis CFUs, spleen CFU levels were intermediate to those in C57BL/6J and 129/Sv
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mortality/aging
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• die within 10 months of age
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immune system
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• develop splenomegaly as early as 6 weeks of age
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• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen
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• splenocytes did not secrete IFN-gamma in response to LPS treatment
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• splenocytes did not secrete IL-12 in response to LPS/IFN-gamma
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• increased susceptibility to Mycobacterium bovis (BCG) infection
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neoplasm
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• develop fatal leukemia, characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen
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hematopoietic system
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• develop splenomegaly as early as 6 weeks of age
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• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen
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growth/size/body
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• develop splenomegaly as early as 6 weeks of age
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mortality/aging
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• when infected with 106 Salmonella typhimurium, mice have a shorter time to death than Slc11a1r homozygotes
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immune system
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• when infected with 106 Salmonella typhimurium, mice have a shorter time to death than Slc11a1 homozygotes
• when infected with 106 Salmonella typhimurium, spleen and mesenteric lymph nodes bacterial loads are increased relative to in Slc11a1 homozygotes
• following infection with Salmonella typhimurium, Peyer patches exhibit slightly increased bacterial load compared to in Slc11a1r homozygotes
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immune system
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• mice succumb to 2x1010 CFU Salmonella infection with a median survival of 20 days compared to no death by infection for the control mice
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mortality/aging
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• die within 10 months of age
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neoplasm
immune system
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• increased susceptibility to Mycobacterium bovis (BCG) infection
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immune system
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• increased susceptibility to Mycobacterium bovis (BCG) infection
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immune system
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• increased susceptibility to Mycobacterium bovis (BCG) infection
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hematopoietic system
growth/size/body
immune system
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• increased susceptibility to Mycobacterium bovis (BCG) infection
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immune system
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• increased susceptibility to Mycobacterium bovis (BCG) infection
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