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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc11a1r
host resistance (Bcg/Ity/Lsh)
MGI:1857756
Summary 13 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slc11a1r/Slc11a1r 129/Sv MGI:3036574
hm2
Slc11a1r/Slc11a1r C3H/HeJ-Slc11a1r MGI:3036462
ht3
Slc11a1r/Slc11a1s (129/Sv x BALB/c)F1 MGI:2680055
ht4
Slc11a1s/Slc11a1r (129/Sv x C57BL/6J)F1 MGI:3036576
cx5
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
BXH2/TyJ-Irf8myls MGI:3578951
cx6
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
Slc11a1r/Slc11a1r
involves: 129S2/SvPas MGI:3722760
cx7
Casp1tm1Sesh/Casp1tm1Sesh
Casp4del/Casp4del
Slc11a1r/Slc11a1s
involves: 129/Sv * 129S2/SvPas * C57BL/6 MGI:3851240
cx8
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
involves: A/J * BXH2/TyJ MGI:3578958
cx9
Irf8myls/Irf8myls
Slc11a1r/Slc11a1s
involves: BALB/cJ * BXH2/TyJ MGI:3578955
cx10
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
involves: BALB/cJ * BXH2/TyJ MGI:3578956
cx11
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
involves: BXH2/TyJ * C3H/HeJ MGI:3578957
cx12
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
involves: BXH2/TyJ * C57BL/6J MGI:3578953
cx13
Irf8myls/Irf8myls
Slc11a1r/Slc11a1s
involves: BXH2/TyJ * C57BL/6J MGI:3578952


Genotype
MGI:3036574
hm1
Allelic
Composition
Slc11a1r/Slc11a1r
Genetic
Background
129/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a1r mutation (2 available); any Slc11a1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased resistance to mycobacterial infection during the early but not the late phase of acquired immunity
• spleen bacterial loads in mice infected with 103 Salmonella CFUs increased steadily from day 1 until day 7, then declined sharply by day 21, and were almost undetectable by day 42 postinfection




Genotype
MGI:3036462
hm2
Allelic
Composition
Slc11a1r/Slc11a1r
Genetic
Background
C3H/HeJ-Slc11a1r
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a1r mutation (2 available); any Slc11a1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased resistance to mycobacterial infection during the early but not the late phase of acquired immunity
• little or no bacterial proliferation in the spleen at any time following BCG inoculation




Genotype
MGI:2680055
ht3
Allelic
Composition
Slc11a1r/Slc11a1s
Genetic
Background
(129/Sv x BALB/c)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a1r mutation (2 available); any Slc11a1 mutation (29 available)
Slc11a1s mutation (0 available); any Slc11a1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• little or no bacterial proliferation was observed in the spleen at any time following BCG inoculation




Genotype
MGI:3036576
ht4
Allelic
Composition
Slc11a1s/Slc11a1r
Genetic
Background
(129/Sv x C57BL/6J)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a1r mutation (2 available); any Slc11a1 mutation (29 available)
Slc11a1s mutation (0 available); any Slc11a1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 42 days after IV injection of 103 Salmonella enteritidis CFUs, spleen CFU levels were intermediate to those in C57BL/6J and 129/Sv




Genotype
MGI:3578951
cx5
Allelic
Composition
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
Genetic
Background
BXH2/TyJ-Irf8myls
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (0 available); any Irf8 mutation (6 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die within 10 months of age

immune system
• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen
• develop splenomegaly as early as 6 weeks of age
• splenocytes did not secrete IFN-gamma in response to LPS treatment
• splenocytes did not secrete IL-12 in response to LPS/IFN-gamma
• increased susceptibility to Mycobacterium bovis (BCG) infection

neoplasm
• develop fatal leukemia, characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen

hematopoietic system
• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen
• develop splenomegaly as early as 6 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
familial chronic myelocytic leukemia-like syndrome DOID:0060761 OMIM:600080
J:97931




Genotype
MGI:3722760
cx6
Allelic
Composition
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
Slc11a1r/Slc11a1r
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Flv mutation (2 available); any Casp1 mutation (27 available)
Casp4del mutation (3 available); any Casp4 mutation (23 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• when infected with 106 Salmonella typhimurium, mice have a shorter time to death than Slc11a1r homozygotes

immune system
• when infected with 106 Salmonella typhimurium, mice have a shorter time to death than Slc11a1 homozygotes
• when infected with 106 Salmonella typhimurium, spleen and mesenteric lymph nodes bacterial loads are increased relative to in Slc11a1 homozygotes
• following infection with Salmonella typhimurium, Peyer patches exhibit slightly increased bacterial load compared to in Slc11a1r homozygotes




Genotype
MGI:3851240
cx7
Allelic
Composition
Casp1tm1Sesh/Casp1tm1Sesh
Casp4del/Casp4del
Slc11a1r/Slc11a1s
Genetic
Background
involves: 129/Sv * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Sesh mutation (4 available); any Casp1 mutation (27 available)
Casp4del mutation (3 available); any Casp4 mutation (23 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (29 available)
Slc11a1s mutation (0 available); any Slc11a1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice succumb to 2x1010 CFU Salmonella infection with a median survival of 20 days compared to no death by infection for the control mice




Genotype
MGI:3578958
cx8
Allelic
Composition
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
Genetic
Background
involves: A/J * BXH2/TyJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (0 available); any Irf8 mutation (6 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die within 10 months of age

neoplasm

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
familial chronic myelocytic leukemia-like syndrome DOID:0060761 OMIM:600080
J:97931




Genotype
MGI:3578955
cx9
Allelic
Composition
Irf8myls/Irf8myls
Slc11a1r/Slc11a1s
Genetic
Background
involves: BALB/cJ * BXH2/TyJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (0 available); any Irf8 mutation (6 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (29 available)
Slc11a1s mutation (0 available); any Slc11a1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased susceptibility to Mycobacterium bovis (BCG) infection




Genotype
MGI:3578956
cx10
Allelic
Composition
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
Genetic
Background
involves: BALB/cJ * BXH2/TyJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (0 available); any Irf8 mutation (6 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased susceptibility to Mycobacterium bovis (BCG) infection




Genotype
MGI:3578957
cx11
Allelic
Composition
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
Genetic
Background
involves: BXH2/TyJ * C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (0 available); any Irf8 mutation (6 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased susceptibility to Mycobacterium bovis (BCG) infection

hematopoietic system




Genotype
MGI:3578953
cx12
Allelic
Composition
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
Genetic
Background
involves: BXH2/TyJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (0 available); any Irf8 mutation (6 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased susceptibility to Mycobacterium bovis (BCG) infection




Genotype
MGI:3578952
cx13
Allelic
Composition
Irf8myls/Irf8myls
Slc11a1r/Slc11a1s
Genetic
Background
involves: BXH2/TyJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (0 available); any Irf8 mutation (6 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (29 available)
Slc11a1s mutation (0 available); any Slc11a1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased susceptibility to Mycobacterium bovis (BCG) infection





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory