All Phenotypes Slc11a1<s> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Slc11a1^s
pathogen susceptibility (Bcg/Ity/Lsh)
MGI:1857755

Summary

14 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc11a1^s/Slc11a1^s	BALB/c	MGI:2680038
hm2	Slc11a1^s/Slc11a1^s	C57BL/6J	MGI:2679989
ht3	Slc11a1^r/Slc11a1^s	(129/Sv x BALB/c)F1	MGI:2680055
ht4	Slc11a1^s/Slc11a1^r	(129/Sv x C57BL/6J)F1	MGI:3036576
ht5	Slc11a1^tm1Mcg/Slc11a1^s	involves: 129S4/SvJae * BALB/c	MGI:2679898
cx6	Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del Slc11a1^s/Slc11a1^s	B6.129S2-Casp1^tm1Flv	MGI:3722759
cx7	Casp1^tm1Sesh/Casp1^tm1Sesh Casp4^del/Casp4^del Slc11a1^s/Slc11a1^s	B6.129S2-Casp1^tm1Sesh Casp4^del	MGI:3851239
cx8	Nlrc4^tm1Gln/Nlrc4^tm1Gln Slc11a1^s/Slc11a1^s	B6.129S5-Nlrc4^tm1Gln	MGI:3722758
cx9	Nlrp3^tm1Flv/Nlrp3^tm1Flv Slc11a1^s/Slc11a1^s	B6.129S5-Nlrp3^tm1Flv	MGI:3722761
cx10	Pycard^tm1Flv/Pycard^tm1Flv Slc11a1^s/Slc11a1^s	B6.129S5-Pycard^tm1Flv	MGI:3722762
cx11	Casp1^tm1Sesh/Casp1^tm1Sesh Casp4^del/Casp4^del Slc11a1^r/Slc11a1^s	involves: 129/Sv * 129S2/SvPas * C57BL/6	MGI:3851240
cx12	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^s	involves: BALB/cJ * BXH2/TyJ	MGI:3578955
cx13	Irf8^myls/Irf8^myls Slc11a1^s/Slc11a1^s	involves: BALB/cJ * BXH2/TyJ	MGI:3578954
cx14	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^s	involves: BXH2/TyJ * C57BL/6J	MGI:3578952

Allelic Composition	Slc11a1^s/Slc11a1^s
Genetic Background	BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a1^s mutation (0 available); any Slc11a1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to bacterial infection ( J:28278 )

• increased susceptibility to mycobacterial infection during the early but not the late phase of acquired immunity

• rapid, uncontrolled bacterial proliferation in the early phase of BCG infection, reaching a maximum at 3 wk

• the spleen BCG load was decreased at 6 weeks after infection

Allelic Composition	Slc11a1^s/Slc11a1^s
Genetic Background	C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a1^s mutation (0 available); any Slc11a1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to bacterial infection ( J:81412 )

• increased susceptibility to mycobacterial infection during the early but not the late phase of acquired immunity

• after initial infection with 10³ Salmonella enteriditis CFUs, spleen bacterial loads declined sharply by day 21, and were nearly undetectable by day 42 postinfection

Allelic Composition	Slc11a1^r/Slc11a1^s
Genetic Background	(129/Sv x BALB/c)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a1^r mutation (2 available); any Slc11a1 mutation (40 available)
Slc11a1^s mutation (0 available); any Slc11a1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to bacterial infection ( J:28278 )

• little or no bacterial proliferation was observed in the spleen at any time following BCG inoculation

Allelic Composition	Slc11a1^s/Slc11a1^r
Genetic Background	(129/Sv x C57BL/6J)F1

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal susceptibility to bacterial infection ( J:81412 )

• 42 days after IV injection of 10³ Salmonella enteritidis CFUs, spleen CFU levels were intermediate to those in C57BL/6J and 129/Sv

Allelic Composition	Slc11a1^tm1Mcg/Slc11a1^s
Genetic Background	involves: 129S4/SvJae * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a1^s mutation (0 available); any Slc11a1 mutation (40 available)
Slc11a1^tm1Mcg mutation (0 available); any Slc11a1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to bacterial infection ( J:28278 )

• compound heterozygous mice were susceptible to early phase infection with BCG or L. donovani or S. typhimurium

• mice showed rapid early BCG proliferation, a maximum bacterial load peaking at 3 weeks, and reduction of the BCG load by 6 weeks after infection

Allelic Composition	Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del Slc11a1^s/Slc11a1^s
Genetic Background	B6.129S2-Casp1^tm1Flv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1^tm1Flv mutation (2 available); any Casp1 mutation (41 available)
Casp4^del mutation (4 available); any Casp4 mutation (30 available)
Slc11a1^s mutation (0 available); any Slc11a1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:124378 )

• when infected with 10⁵ Salmonella typhimurium, mice exhibit increased mortality compared to wild-type mice

immune system

cecum inflammation ( J:124378 )

• the ceca of mice infected with Salmonella typhimurium and treated with streptomycin exhibit increased inflammation with more edema, more neutrophil infiltration and epithelial disruption

increased susceptibility to bacterial infection ( J:124378 )

• when infected with 10⁵ Salmonella typhimurium, mice exhibit increased mortality compared to wild-type mice

• when infected with 10⁶ Salmonella typhimurium, spleen and mesenteric lymph nodes bacterial loads are increased to a greater extent than in either single allele homozygote

• following infection with Salmonella typhimurium, Peyer patches exhibit slightly increased bacterial load compared to in Slc11a1^s homozygotes

digestive/alimentary system

cecum inflammation ( J:124378 )

• the ceca of mice infected with Salmonella typhimurium and treated with streptomycin exhibit increased inflammation with more edema, more neutrophil infiltration and epithelial disruption

Allelic Composition	Casp1^tm1Sesh/Casp1^tm1Sesh Casp4^del/Casp4^del Slc11a1^s/Slc11a1^s
Genetic Background	B6.129S2-Casp1^tm1Sesh Casp4^del

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1^tm1Sesh mutation (5 available); any Casp1 mutation (41 available)
Casp4^del mutation (4 available); any Casp4 mutation (30 available)
Slc11a1^s mutation (0 available); any Slc11a1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal macrophage physiology ( J:112400 )

• macrophages are resistant to cytotoxicity induced by in vitro Salmonella infection

increased susceptibility to bacterial infection ( J:112400 )

• mice succumb more rapidly than controls to 10⁸ CFU of Salmonella with a median survival time of 6 days compared to 8 days for controls

• there is an average 30-fold-higher bacterial loads in infected Peyer's patches, mesenteric lymph nodes, and spleens than in the infected organs of wild-type animals

hematopoietic system

abnormal macrophage physiology ( J:112400 )

• macrophages are resistant to cytotoxicity induced by in vitro Salmonella infection

Allelic Composition	Nlrc4^tm1Gln/Nlrc4^tm1Gln Slc11a1^s/Slc11a1^s
Genetic Background	B6.129S5-Nlrc4^tm1Gln

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4^tm1Gln mutation (0 available); any Nlrc4 mutation (67 available)
Slc11a1^s mutation (0 available); any Slc11a1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to bacterial infection ( J:124378 )

• when infected with 10⁵ Salmonella typhimurium, mice exhibit increased mortality similar to in Slc11a1^s homozygotes

• when infected with 10⁵ Salmonella typhimurium, spleen and mesenteric lymph nodes bacterial loads are increased similar to in Slc11a1^s homozygotes

Allelic Composition	Nlrp3^tm1Flv/Nlrp3^tm1Flv Slc11a1^s/Slc11a1^s
Genetic Background	B6.129S5-Nlrp3^tm1Flv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3^tm1Flv mutation (1 available); any Nlrp3 mutation (61 available)
Slc11a1^s mutation (0 available); any Slc11a1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:124378 )

• when infected with 10⁵ Salmonella typhimurium, mice succumb within the same timeframe as Slc11a1^s homozygotes

immune system

increased susceptibility to bacterial infection ( J:124378 )

• when infected with 10⁵ Salmonella typhimurium, mice succumb within the same timeframe as Slc11a1^s homozygotes

• when infected with 10⁵ Salmonella typhimurium, spleen and mesenteric lymph nodes bacterial loads are increased similar to in Slc11a1^s homozygotes

Allelic Composition	Pycard^tm1Flv/Pycard^tm1Flv Slc11a1^s/Slc11a1^s
Genetic Background	B6.129S5-Pycard^tm1Flv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pycard^tm1Flv mutation (0 available); any Pycard mutation (13 available)
Slc11a1^s mutation (0 available); any Slc11a1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to bacterial infection ( J:124378 )

• when infected with Salmonella typhimurium, mice succumb within the same timeframe as Slc11a1^s homozygotes

• when infected with Salmonella typhimurium, spleen and mesenteric lymph nodes bacterial loads are increased similar to in Slc11a1^s homozygotes

Allelic Composition	Casp1^tm1Sesh/Casp1^tm1Sesh Casp4^del/Casp4^del Slc11a1^r/Slc11a1^s
Genetic Background	involves: 129/Sv * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1^tm1Sesh mutation (5 available); any Casp1 mutation (41 available)
Casp4^del mutation (4 available); any Casp4 mutation (30 available)
Slc11a1^r mutation (2 available); any Slc11a1 mutation (40 available)
Slc11a1^s mutation (0 available); any Slc11a1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to bacterial infection ( J:112400 )

• mice succumb to 2x10¹⁰ CFU Salmonella infection with a median survival of 20 days compared to no death by infection for the control mice

Allelic Composition	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^s
Genetic Background	involves: BALB/cJ * BXH2/TyJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8^myls mutation (1 available); any Irf8 mutation (32 available)
Slc11a1^r mutation (2 available); any Slc11a1 mutation (40 available)
Slc11a1^s mutation (0 available); any Slc11a1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to bacterial infection ( J:97931 )

• increased susceptibility to Mycobacterium bovis (BCG) infection

Allelic Composition	Irf8^myls/Irf8^myls Slc11a1^s/Slc11a1^s
Genetic Background	involves: BALB/cJ * BXH2/TyJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8^myls mutation (1 available); any Irf8 mutation (32 available)
Slc11a1^s mutation (0 available); any Slc11a1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to bacterial infection ( J:97931 )

• increased susceptibility to Mycobacterium bovis (BCG) infection

Allelic Composition	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^s
Genetic Background	involves: BXH2/TyJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to bacterial infection ( J:97931 )

• increased susceptibility to Mycobacterium bovis (BCG) infection

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