Mouse Genome Informatics
hm1
    Cnr1tm1Map/Cnr1tm1Map
B6.129-Cnr1tm1Map
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
taste/olfaction
• mice fail to exhibit the 2-arachidonoyl glycerol sweet enhancing nerve response and increased licking unlike in wild-type mice

nervous system
• mice fail to exhibit the 2-arachidonoyl glycerol sweet enhancing nerve response unlike in wild-type mice


Mouse Genome Informatics
hm2
    Cnr1tm1Map/Cnr1tm1Map
involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
reproductive system
• mice exhibit increased motile spermatozoa in the caput compared with wild-type mice (J:123226)

skeleton
N
• osteoclast and osteoblast numbers are normal (J:105218)
• ovariectomized mice do not exhibit a decrease in bone mineral density unlike similarly treated wild-type mice
• in the spine, spine, and tibial metaphysis

nervous system
• mice fail to exhibit depolarization-induced suppression of inhibition unlike wild-type mice


Mouse Genome Informatics
hm3
    Cnr1tm1Map/Cnr1tm1Map
involves: 129S1/Sv * 129X1/SvJ * CD-1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• following middle cerebral artery occlusion (MCA), mice exhibit a 5-fold increase in mortality compared with similarly treated wild-type mice

behavior/neurological
• unlike in wild-type mice, there is no decrease in horizontal locomotor activity or rectal temperature following treatment with delta9-tetrahydrocannabinol (delta9-THC)
• in an intravenous self-administration model, the number of nose pokes leading to WIN55,212-2 administration are reduced compared to wild-type mice
• unlike in wild-type mice, there is no abstinence when treated with the Cnr1-receptor antagonist SR141.716A following long term exposure to delta-THC
• unlike wild-type mice, there is no hypotensive response to anandamide or WIN55,212-2
• in an intravenous self-administration model, the number of nose pokes leading to morphine administration are reduced compared to wild-type mice
• naloxine-precipitated morphine withdrawal symptoms are decreased compared to in wild-type mice
• in response to chronic unpredictable mild stress, mice exhibit increased depressive-like behavior compared with wild-type mice
• in response to chronic unpredictable mild stress, mice exhibit increased depressive-like behavior compared with wild-type mice
• in an elevated plus maze, mice spend less time exploring open arms compared with wild-type mice (J:89437)
• however, mice treated with the cannabinoid antagonist SR141716A exhibit a normal reduction in anxiety (J:89437)
• under high light conditions, mice exhibit increased anxiety-related behavior in an elevated plus maze compared with wild-type mice (J:89722)
• however, behavior in an elevated plus maze under low light conditions is normal (J:89722)
• in a light/dark box (J:103942)
• when newly exposed to the arena, mice exhibit a moderate increase in locomotor activity to 119% of wild-type mice
• mice exhibit increased exploratory behavior under stressful conditions of an open field and in the spontaneous alteration test (58.9+/-2.2 visits to the arms compared to 47.2+/-1.6 visits to the arms for wild-type mice)
• mice exhibit a decrease in spontaneous alternations in a Y maze (53.7+/-1.9% compared to 61.4+/-1.8% for wild-type mice)
• however, the number of entries and time spent in the open arms in an elevated plus maze are normal
• time spent exploring an unknown object is increased (5.33+/-1.5 s compared to 0.66+/-0.3 s for wild-type mice)
• in an active avoidance test, mice exhibit increased conditioned responses compared with wild-type mice
• the dysphoric effect on conditioned place aversion by U-50,488H is not observed in mutant mice
• however, activity levels are normal after habituation
• when newly exposed to the arena, mice exhibit a moderate increase in locomotor activity to 119% of wild-type mice
• the antinociception effect of delta9-tetrahydrocannabinol (THC) is abolished when mice are subjected to a hot-plate test and strongly reduced when subjected to a tail-immersion test
• however, the antinociceptive effect of morphine and U-50,488H and the tolerance development for morphine are unaltered
• in an unfamiliar cage, mice exhibit decreased social interaction compared with wild-type mice
• mice exhibit increased aggression towards other mice in a home cage compared with wild-type mice (J:89722)
• in a resident-intruder test (J:103942)

nervous system
• lesions induced by NMDA are twice as large as in similarly treated wild-type mice
• neuronal precursor cell proliferation in the dorsal ganglion and subventricular zone (SVZ) is decreased 50% compared to in wild-type mice
• SR141716A increases proliferation in the dorsal ganglion to a greater extent than in similarly treated wild-type mice
• AM251 induces proliferation in the dorsal ganglion and SVZ unlike in similarly treated wild-type mice
• ollowing middle cerebral artery occlusion (MCA), mice exhibit a 5-fold increase in mortality compared with similarly treated wild-type mice
• following middle cerebral artery occlusion (MCA)

homeostasis/metabolism
• slightly but significantly more sensitive to 3NP intoxication
• lesions induced by NMDA are twice as large as in similarly treated wild-type mice
• ollowing middle cerebral artery occlusion (MCA), mice exhibit a 5-fold increase in mortality compared with similarly treated wild-type mice
• following middle cerebral artery occlusion (MCA)

integument
• the antinociception effect of delta9-tetrahydrocannabinol (THC) is abolished when mice are subjected to a hot-plate test and strongly reduced when subjected to a tail-immersion test
• however, the antinociceptive effect of morphine and U-50,488H and the tolerance development for morphine are unaltered

cellular
• lesions induced by NMDA are twice as large as in similarly treated wild-type mice
• neuronal precursor cell proliferation in the dorsal ganglion and subventricular zone (SVZ) is decreased 50% compared to in wild-type mice
• SR141716A increases proliferation in the dorsal ganglion to a greater extent than in similarly treated wild-type mice
• AM251 induces proliferation in the dorsal ganglion and SVZ unlike in similarly treated wild-type mice


Mouse Genome Informatics
ht4
    Cnr1tm1Map/Cnr1+
involves: 129S1/Sv * 129X1/SvJ * CD-1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• following middle cerebral artery occlusion (MCA)

nervous system
• following middle cerebral artery occlusion (MCA)


Mouse Genome Informatics
cx5
    Cnr1tm1Map/Cnr1tm1Map
Tg(SOD1*G93A)1Gur/0

involves: 129S1/Sv * 129X1/SvJ * ABH * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• despite similar disease progression, mice exhibit longer life span compared with Tg(SOD1*G93A)1Gur mice


Mouse Genome Informatics
cx6
    Cnr1tm1Map/Cnr1tm1Map
Tg(HD82Gln)81Gschi/0

involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * CD-1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• reduced lifespan compared to wild-type controls
• however lifespan is similar to transgenic mice wild-type for Cnr1

nervous system
• increase in the density of ubiquitin positive aggregates in the striatum compared to transgenic mice wild-type for Cnr1

behavior/neurological
• reduced latency to fall and an increased number of falls in a rotarod assay
• motor performance is worse than in transgenic mice wild-type for Cnr1

growth/size/body
• fail to gain weight after 16 weeks of age
• fail to gain weight after 16 weeks of age

Mouse Models of Human Disease
OMIM IDRef(s)
Huntington Disease; HD 143100 J:172874