Analysis Tools
embryo
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• not rescued by blocking programmed cell death or activating insulin-like growth factor I receptor signaling
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Allele Symbol Allele Name Allele ID |
Cdh1tm1Kem targeted mutation 1, Rolf Kemler MGI:1857282 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• not rescued by blocking programmed cell death or activating insulin-like growth factor I receptor signaling
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• death between E3.5-E4.5
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• failure to form blastocyst cavity
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• failure to form trophectodermal epithelium
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when treated with a cre-expressing plasmid, embryonic stem cells from E3.5 mice exhibit reduced cell to cell adhesion compared to wild-type embryonic cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• on day 16 of pregnancy, mammary glands of pregnant mice show only occasional and small units of secretion compared to wild-type mice; this becomes more striking by day 18 and at parturition
• mammary gland is disorganized, with poorly developed, condensed alveoli at parturition
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• at day 2 of lactation, majority of lobulo-alveolar structures have collapsed, leaving clusters of epithelial cords with small lumina and extensive tissue remodeling
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• on day 16 of pregnancy, mammary glands of pregnant mice show only occasional and small units of secretion compared to wild-type mice; this becomes more striking by day 18 and at parturition
• mammary gland is disorganized, with poorly developed, condensed alveoli at parturition
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• expression of B-casein and whey acidic protein (WAP) re drastically reduced in mammary glands during lactation, indicating that gland is inefficient at producing milk proteins
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• mutant mice cannot nurse their offspring due to mammary gland defects; 80% of offspring die within 24 hours and all die within 2-3 days of birth
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• at day 2 of lactation, majority of lobulo-alveolar structures have collapsed, leaving clusters of epithelial cords with small lumina and extensive tissue remodeling
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• on day 16 of pregnancy, mammary glands of pregnant mice show only occasional and small units of secretion compared to wild-type mice; this becomes more striking by day 18 and at parturition
• mammary gland is disorganized, with poorly developed, condensed alveoli at parturition
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• expression of B-casein and whey acidic protein (WAP) re drastically reduced in mammary glands during lactation, indicating that gland is inefficient at producing milk proteins
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• mutant mice cannot nurse their offspring due to mammary gland defects; 80% of offspring die within 24 hours and all die within 2-3 days of birth
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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