Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4tm1Litt mutation
(4 available);
any
Cd4 mutation
(82 available)
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immune system
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• CD4 T cells have decreased levels of proliferation in mixed lymphocyte cultures with cells expressing class II alloantigen
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• mice exhibit a near complete absence of CD4 expression in thymocytes, lamina propria lin-c-kit+CD127+ cells, and splenic TCRbeta-CD19-MHCII+CD11c+ cells compared to in wild-type mice
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• CD4 T cells are absent from both the thymus and the periphery
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• 90% of peripheral alphabeta T cell are CD8-positive
(J:50435)
• 93% of thymocytes are CD8-positive
(J:50435)
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• antibody production by B cells in response to the T cell dependent antigen TNP-KLH is 10-fold less than in controls
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hematopoietic system
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• CD4 T cells have decreased levels of proliferation in mixed lymphocyte cultures with cells expressing class II alloantigen
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• mice exhibit a near complete absence of CD4 expression in thymocytes, lamina propria lin-c-kit+CD127+ cells, and splenic TCRbeta-CD19-MHCII+CD11c+ cells compared to in wild-type mice
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• CD4 T cells are absent from both the thymus and the periphery
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• 90% of peripheral alphabeta T cell are CD8-positive
(J:50435)
• 93% of thymocytes are CD8-positive
(J:50435)
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• antibody production by B cells in response to the T cell dependent antigen TNP-KLH is 10-fold less than in controls
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cellular
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• CD4 T cells have decreased levels of proliferation in mixed lymphocyte cultures with cells expressing class II alloantigen
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4tm1Litt mutation
(4 available);
any
Cd4 mutation
(82 available)
Cd4tm1Nik mutation
(2 available);
any
Cd4 mutation
(82 available)
Tg(Lck-cre)3778Nik mutation
(0 available)
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immune system
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• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls
• however, T cells are capable of proliferating in vivo in response to antigenic stimulation
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• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls
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• TH2-mediated IL-4 secretion is impaired but TH1 responses are normal
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• TH2-mediated IL-4 secretion is impaired but TH1 responses are normal
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hematopoietic system
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• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls
• however, T cells are capable of proliferating in vivo in response to antigenic stimulation
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• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls
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• TH2-mediated IL-4 secretion is impaired but TH1 responses are normal
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cellular
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• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls
• however, T cells are capable of proliferating in vivo in response to antigenic stimulation
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immune system
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• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls
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• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls
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hematopoietic system
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• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls
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• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls
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cellular
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• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4tm1Litt mutation
(4 available);
any
Cd4 mutation
(82 available)
Cd4tm1Nik mutation
(2 available);
any
Cd4 mutation
(82 available)
Tg(Lck-cre)3785Nik mutation
(0 available)
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immune system
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• increase in apoptosis of CD4 lineage T cells
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• increase in proliferation of peripheral CD4 lineage cells
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• few peripheral CD4 lineage T cells
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• increase in CD8+ T cells in lymph nodes
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• CD4 lineage T cells exhibit an increase in proliferation and apoptosis
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hematopoietic system
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• increase in apoptosis of CD4 lineage T cells
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• increase in proliferation of peripheral CD4 lineage cells
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• few peripheral CD4 lineage T cells
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• increase in CD8+ T cells in lymph nodes
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• CD4 lineage T cells exhibit an increase in proliferation and apoptosis
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cellular
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• increase in apoptosis of CD4 lineage T cells
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• increase in proliferation of peripheral CD4 lineage cells
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immune system
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• about 3 fold increase in percentage of double negative alpha-beta T cells that are found in the lymph node
• about 4 fold increase in number of double negative alpha-beta T cells that are found in the spleen
• about 5 fold increase in in percentage of double negative alpha-beta T cells that are found in the thymus
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• impaired T-cell dependent B cell response to foreign antigen
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hematopoietic system
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• about 3 fold increase in percentage of double negative alpha-beta T cells that are found in the lymph node
• about 4 fold increase in number of double negative alpha-beta T cells that are found in the spleen
• about 5 fold increase in in percentage of double negative alpha-beta T cells that are found in the thymus
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• impaired T-cell dependent B cell response to foreign antigen
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mortality/aging
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• signs of scurfy disease are delayed and are first seen at 4 weeks of age, with mutants dying at about 6 weeks of age
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immune system
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• increase in the percentage of CD4-CD8+CD44+ and CD4-CD8+CD45RBdull T cells compared to homozygous CD4 mice at 15 days of age
• decrease in the percentage of CD4-CD8+ T cells in aged mutants compared with aged homozygous CD4 mice
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• increased IgG in 35 day or older mutants, but not in 15 day old mutants
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• increased IgM in 35 day or older mutants, but not in 15 day old mutants
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• lymphoid organs in 15 day old mutants have typical scurfy lesions in T cell areas, but quiescent B cell areas
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• lymph nodes are normal size at day 15 but are enlarged by day 35
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• increased IL-4 production in response to Con A stimulation in aged (P45), but not young (P16) mice, compared to homozygous Cd4 mutant mice
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• increased IL-6 production in response to Con A stimulation in aged (P45), but not young (P16) mice, compared to homozygous Cd4 mutant mice
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• increased TNF-alpha production in response to Con A stimulation in aged (P45), but not young (P16) mice, compared to homozygous Cd4 mutant mice
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hematopoietic system
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• increase in the percentage of CD4-CD8+CD44+ and CD4-CD8+CD45RBdull T cells compared to homozygous CD4 mice at 15 days of age
• decrease in the percentage of CD4-CD8+ T cells in aged mutants compared with aged homozygous CD4 mice
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• increased IgG in 35 day or older mutants, but not in 15 day old mutants
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• increased IgM in 35 day or older mutants, but not in 15 day old mutants
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4tm1Litt mutation
(4 available);
any
Cd4 mutation
(82 available)
Tg(Cd4-CD4)2362Litt mutation
(3 available)
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immune system
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• the human CD4 transgene rescues the phenotype associated with Cd4tm1Litt homozygotes
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Analysis Tools