All Phenotypes Tcra<tm1Mom> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tcra^tm1Mom
targeted mutation 1, Peter Mombaerts
MGI:1857255

Summary

19 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcra^tm1Mom/Tcra^tm1Mom	B6.129S2-Tcra^tm1Mom	MGI:3620217
hm2	Tcra^tm1Mom/Tcra^tm1Mom	involves: 129S2/SvPas	MGI:2429507
hm3	Tcra^tm1Mom/Tcra^tm1Mom	involves: 129S2/SvPas * C57BL/6	MGI:3767323
cn4	Nr3c1^tm1.1Jda/Nr3c1^tm1.1Jda Tcra^tm1Mom/Tcra^tm1Mom Tg(Lck-cre)548Jxm/0	B6.Cg-Tcra^tm1Mom Nr3c1^tm1.1Jda Tg(Lck-cre)548Jxm	MGI:5447538
cn5	Bcl11b^tm1Avram/Bcl11b^tm1Avram Tcra^tm1Mom/Tcra^tm1Mom Tg(Cd4-cre)1Cwi/?	involves: 129 * C57BL/6 * DBA/2	MGI:3767630
cx6	H2-T18^b/H2-T18^b H2-T3^tm1Luc/H2-T3^tm1Luc Tcra^tm1Mom/Tcra^tm1Mom	B6.Cg-Tcra^tm1Mom H2-T3^tm1Luc	MGI:3822756
cx7	Tcra^tm1Mom/Tcra^tm1Mom Tcrb^tm1Mom/Tcrb^tm1Mom	involves: 129 * BALB/c * C57BL/6	MGI:3769898
cx8	Prkcq^tm1Litt/Prkcq^tm1Litt Tcra^tm1Mom/Tcra^tm1Mom	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:4843514
cx9	Tcra^tm1Mom/Tcra^tm1Mom Tcra-J^tm1Kgwa/Tcra-J^tm1Kgwa	involves: 129P2/OlaHsd * 129S2/SvPas * C3H/HeJ * C57BL/6J	MGI:3688410
cx10	Tcra^tm1Mom/Tcra^tm1Mom Tcrg^tm1.1Hish/Tcrg^tm1.1Hish	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:3803245
cx11	Rr100^tm2.1Welm/Rr100^tm2.1Welm Tcra^tm1Mom/Tcra^tm1Mom	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:3698424
cx12	Tcra^tm1Mom/Tcra^tm1Mom Trex1^tm1Tld/Trex1^tm1Tld	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:5317332
cx13	Tcra^tm1Mom/Tcra^tm1Mom Tg(CD19-Tnfsf7)#Rvl/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3716180
cx14	Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} H2^d/H2^d Ptcra^tm1Vbo/Ptcra^tm1Vbo Tg(Tcrb)93Vbo/?	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807288
cx15	H2^b/H2^b Ptcra^tm1Vbo/Ptcra^tm1Vbo Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} Tg(Tcrb)93Vbo/?	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807286
cx16	Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} H2^b/H2^b Tg(Tcrb)93Vbo/?	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807222
cx17	H2^b/H2^b Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} Tg(Tcrb)93Vbo/?	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807217
cx18	Tcra^tm1Mom/Tcra^tm1Mom Tg(Lck-Akt1*E40K)E-3Pnt/0	involves: 129S2/SvPas * C3H/He * C57BL/6	MGI:3803976
cx19	Tcra^tm1Mom/Tcra^tm1Mom Tg(TcraAV19AJ33)1Shima/?	involves: 129S2/SvPas * C57BL/6	MGI:3814868

Allelic Composition	Tcra^tm1Mom/Tcra^tm1Mom
Genetic Background	B6.129S2-Tcra^tm1Mom

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra^tm1Mom mutation (6 available); any Tcra mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

colitis ( J:135597 )

• a disease similar to ulcerative colitis occurs in these mice with histology revealing inflammation and elongation of the crypts

increased mature gamma-delta T cell number ( J:135597 )

• there are 20-fold more gammadelta T cells found in the lamina propia of the gut compared to wild-type mice

increased susceptibility to bacterial infection ( J:106241 )

• greatly increased susceptibility to infection with Mycobacterium paratuberculosis

abnormal response to transplant ( J:91742 )

• mice fail to reject tail skin from OVA expressing transgenic mice ( Tg(CAG-OVA)916Jen )

digestive/alimentary system

abnormal large intestine morphology ( J:135597 )

• colitis results in lengthening of the colon

• the large intestine weight to body weight ratio at 28 weeks of age is twice as great than what is observed in wild-type mice

rectal prolapse ( J:135597 )

• rectal prolapse occurs in about 18% of mice 24 to 60 weeks of age

colitis ( J:135597 )

• a disease similar to ulcerative colitis occurs in these mice with histology revealing inflammation and elongation of the crypts

hematopoietic system

increased mature gamma-delta T cell number ( J:135597 )

• there are 20-fold more gammadelta T cells found in the lamina propia of the gut compared to wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
inflammatory bowel disease		DOID:0050589	OMIM:PS266600	J:135597

Allelic Composition	Tcra^tm1Mom/Tcra^tm1Mom
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra^tm1Mom mutation (6 available); any Tcra mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

absent T cells ( J:88620 )

hematopoietic system

absent T cells ( J:88620 )

Allelic Composition	Tcra^tm1Mom/Tcra^tm1Mom
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra^tm1Mom mutation (6 available); any Tcra mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

colitis ( J:15221 )

• colitis occurs in mice as they age (4 months and over)

• disease resembles the human disease ulcerative colitis

arrested T cell differentiation ( J:3206 )

• T cells in the thymus do not pass the double positive stage

decreased CD4-positive, alpha-beta T cell number ( J:3206 )

• very few T cells are found in the thymus or periphery

decreased CD8-positive, alpha-beta T cell number ( J:3206 )

• very few CD8 T cells are found in the thymus or periphery

increased gamma-delta intraepithelial T cell number ( J:15221 )

• numbers are markedly increased

decreased IgG level ( J:119344 )

• mice do not produce IgG following infection, although M. pulmonis-specific IgM antibodies are detected

abnormal response to infection ( J:119344 )

• airway vascular and airway lymphatic vessel remodeling are impaired or absent compared to wild-type mice after M. pulmonis infection

respiratory system

abnormal respiratory system morphology ( J:119344 )

• M. pulmonis infected mice show a diminished or intermediate airway remodeling phenotype when compared to wild-type or Igh-6 deficient mice

hematopoietic system

arrested T cell differentiation ( J:3206 )

• T cells in the thymus do not pass the double positive stage

decreased CD4-positive, alpha-beta T cell number ( J:3206 )

• very few T cells are found in the thymus or periphery

decreased CD8-positive, alpha-beta T cell number ( J:3206 )

• very few CD8 T cells are found in the thymus or periphery

increased gamma-delta intraepithelial T cell number ( J:15221 )

• numbers are markedly increased

decreased IgG level ( J:119344 )

• mice do not produce IgG following infection, although M. pulmonis-specific IgM antibodies are detected

digestive/alimentary system

abnormal intestinal goblet cell morphology ( J:15221 )

• pronounced depletion of goblet cells resulting from inflammation

crypts of Lieberkuhn abscesses ( J:15221 )

• caused by neutrophil infiltration

intestinal ulcer ( J:15221 )

• occurs in rare cases

rectal prolapse ( J:15221 )

• occurs in mice over 4 months of age

chronic diarrhea ( J:15221 )

• is observed in older mice

colitis ( J:15221 )

• colitis occurs in mice as they age (4 months and over)

• disease resembles the human disease ulcerative colitis

endocrine/exocrine glands

crypts of Lieberkuhn abscesses ( J:15221 )

• caused by neutrophil infiltration

mortality/aging

premature death ( J:15221 )

• mortality rates increase after six months of age

• few mice survive longer than one year

cellular

abnormal intestinal goblet cell morphology ( J:15221 )

• pronounced depletion of goblet cells resulting from inflammation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
inflammatory bowel disease		DOID:0050589	OMIM:PS266600	J:15221

Allelic Composition	Nr3c1^tm1.1Jda/Nr3c1^tm1.1Jda Tcra^tm1Mom/Tcra^tm1Mom Tg(Lck-cre)548Jxm/0
Genetic Background	B6.Cg-Tcra^tm1Mom Nr3c1^tm1.1Jda Tg(Lck-cre)548Jxm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1^tm1.1Jda mutation (1 available); any Nr3c1 mutation (34 available)
Tcra^tm1Mom mutation (6 available); any Tcra mutation (98 available)
Tg(Lck-cre)548Jxm mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased double-positive T cell number ( J:189951 )

• in the thymus

hematopoietic system

decreased double-positive T cell number ( J:189951 )

• in the thymus

Allelic Composition	Bcl11b^tm1Avram/Bcl11b^tm1Avram Tcra^tm1Mom/Tcra^tm1Mom Tg(Cd4-cre)1Cwi/?
Genetic Background	involves: 129 * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11b^tm1Avram mutation (0 available); any Bcl11b mutation (45 available)
Tcra^tm1Mom mutation (6 available); any Tcra mutation (98 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

thymus hypoplasia ( J:128515 )

• cellularity is reduced by 42%

abnormal positive T cell selection ( J:128515 )

• slight increase in the number of apoptotic double positive T cells after 16 hours of culturing, indicating apoptosis is occurring independent of TCR signaling

decreased double-positive T cell number ( J:128515 )

• 2.4 fold reduction in the number of DP T cells in thymus

immune system

thymus hypoplasia ( J:128515 )

• cellularity is reduced by 42%

abnormal positive T cell selection ( J:128515 )

• slight increase in the number of apoptotic double positive T cells after 16 hours of culturing, indicating apoptosis is occurring independent of TCR signaling

decreased double-positive T cell number ( J:128515 )

• 2.4 fold reduction in the number of DP T cells in thymus

endocrine/exocrine glands

thymus hypoplasia ( J:128515 )

• cellularity is reduced by 42%

Allelic Composition	H2-T18^b/H2-T18^b H2-T3^tm1Luc/H2-T3^tm1Luc Tcra^tm1Mom/Tcra^tm1Mom
Genetic Background	B6.Cg-Tcra^tm1Mom H2-T3^tm1Luc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-T18^b mutation (12 available); any H2-T18 mutation (52 available)
H2-T3^tm1Luc mutation (1 available); any H2-T3 mutation (25 available)
Tcra^tm1Mom mutation (6 available); any Tcra mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:142515 )

• there is a 35% mortality rate resulting from colitis compared to 8.3% mortality of Tcra^tm1Mom homozygote controls

digestive/alimentary system

colitis ( J:142515 )

• mice have a higher incidence of colitis and a more severe disease than control mice that are only homozygote for the Tcra^tm1Mom null allele

• 83% of mice have colitis compared to 14% of controls at 30 weeks of age

• the first signs of disease occur at 15 weeks of age compared to 20 weeks of age in controls

• higher incidence of pathological lesions occurs in the colon of these mice, including loss of goblet cells, elongation of crypts, and inflammatory infiltration of the colon walls

• there is a 35% mortality rate resulting from colitis compared to 8.3% of controls

immune system

colitis ( J:142515 )

• mice have a higher incidence of colitis and a more severe disease than control mice that are only homozygote for the Tcra^tm1Mom null allele

• 83% of mice have colitis compared to 14% of controls at 30 weeks of age

• the first signs of disease occur at 15 weeks of age compared to 20 weeks of age in controls

• higher incidence of pathological lesions occurs in the colon of these mice, including loss of goblet cells, elongation of crypts, and inflammatory infiltration of the colon walls

• there is a 35% mortality rate resulting from colitis compared to 8.3% of controls

abnormal intraepithelial T cell number ( J:142515 )

• mice have higher numbers of gamma-delta and TCRbeta-beta IEL in the colon both before and after the onset of colitis compared to Tcra^tm1Mom homozygote controls

enlarged mesenteric lymph nodes ( J:142515 )

• mesenteric lymph nodes are enlarged in these mice with about a 2-fold increase in cell number compared to Tcra^tm1Mom homozygote controls

• this increase in cellularity occurs regardless if mice have developed colitis or not

increased interleukin-4 secretion ( J:142515 )

• TCRbeta-beta T cells isolated from the mesenteric lymph nodes produce around 4-fold more IL-4 than controls

hematopoietic system

abnormal intraepithelial T cell number ( J:142515 )

• mice have higher numbers of gamma-delta and TCRbeta-beta IEL in the colon both before and after the onset of colitis compared to Tcra^tm1Mom homozygote controls

Allelic Composition	Tcra^tm1Mom/Tcra^tm1Mom Tcrb^tm1Mom/Tcrb^tm1Mom
Genetic Background	involves: 129 * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra^tm1Mom mutation (6 available); any Tcra mutation (98 available)
Tcrb^tm1Mom mutation (12 available); any Tcrb mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:3206 )

• about a 95% reduction in number of total thymocytes

decreased double-positive T cell number ( J:3206 )

• double positive cells are not present

arrested T cell differentiation ( J:3206 )

• most T cells in the thymus do no progress to the double negative stage

hematopoietic system

thymus hypoplasia ( J:3206 )

• about a 95% reduction in number of total thymocytes

decreased double-positive T cell number ( J:3206 )

• double positive cells are not present

arrested T cell differentiation ( J:3206 )

• most T cells in the thymus do no progress to the double negative stage

endocrine/exocrine glands

thymus hypoplasia ( J:3206 )

• about a 95% reduction in number of total thymocytes

Allelic Composition	Prkcq^tm1Litt/Prkcq^tm1Litt Tcra^tm1Mom/Tcra^tm1Mom
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkcq^tm1Litt mutation (3 available); any Prkcq mutation (51 available)
Tcra^tm1Mom mutation (6 available); any Tcra mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:135589 )

N	• unlike Tcra^tm1Mom homozygotes, mice do not develop colitis

decreased T cell proliferation ( J:135589 )

• colonic T cells exhibit decreased proliferation compared to in Tcra^tm1Mom homozygotes without altering the apoptotic response

decreased interleukin-4 secretion ( J:135589 )

• IL4 is not detected in colonic T cells unlike in Tcra^tm1Mom homozygotes

digestive/alimentary system

digestive/alimentary phenotype ( J:135589 )

N	• unlike Tcra^tm1Mom homozygotes, mice do not develop colitis

hematopoietic system

decreased T cell proliferation ( J:135589 )

• colonic T cells exhibit decreased proliferation compared to in Tcra^tm1Mom homozygotes without altering the apoptotic response

cellular

decreased T cell proliferation ( J:135589 )

• colonic T cells exhibit decreased proliferation compared to in Tcra^tm1Mom homozygotes without altering the apoptotic response

Allelic Composition	Tcra^tm1Mom/Tcra^tm1Mom Tcra-J^tm1Kgwa/Tcra-J^tm1Kgwa
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra-J^tm1Kgwa mutation (0 available); any Tcra-J mutation (0 available)
Tcra^tm1Mom mutation (6 available); any Tcra mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased double-negative T cell number ( J:50143 )

• majority of CD3+ double negative (DN) cells express the transgenic TCR alpha, but only 3-5% of double- and single-positive cells express it

immune system

increased double-negative T cell number ( J:50143 )

• majority of CD3+ double negative (DN) cells express the transgenic TCR alpha, but only 3-5% of double- and single-positive cells express it

Allelic Composition	Tcra^tm1Mom/Tcra^tm1Mom Tcrg^tm1.1Hish/Tcrg^tm1.1Hish
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra^tm1Mom mutation (6 available); any Tcra mutation (98 available)
Tcrg^tm1.1Hish mutation (0 available); any Tcrg mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired macrophage chemotaxis ( J:135597 )

• less macrophages are found in the lamina propia of the gut during colitis than in Tcra^tm1Mom homozygotes

colitis ( J:135597 )

• the colitis associated with Tcra^tm1Mom homozygotes is less severe in these mice with lower histological disease score and no anorectal prolapse

absent gamma-delta T cells ( J:135597 )

• gamma-delta T cells are absent in the periphery including the gut IEL

impaired neutrophil recruitment ( J:135597 )

• less numbers of neutrophils and monocytes are found in the lamina propia of the gut during colitis

• colonic extracts from mice have less ability to enhance migration of neutrophils compared to extracts from Tcra^tm1Mom homozygotes

hematopoietic system

impaired macrophage chemotaxis ( J:135597 )

• less macrophages are found in the lamina propia of the gut during colitis than in Tcra^tm1Mom homozygotes

absent gamma-delta T cells ( J:135597 )

• gamma-delta T cells are absent in the periphery including the gut IEL

impaired neutrophil recruitment ( J:135597 )

• less numbers of neutrophils and monocytes are found in the lamina propia of the gut during colitis

• colonic extracts from mice have less ability to enhance migration of neutrophils compared to extracts from Tcra^tm1Mom homozygotes

digestive/alimentary system

abnormal large intestine morphology ( J:135597 )

• the large intestine weight to body weight ratio at 28 weeks of age is 1.5 fold greater than in wild-type mice in these mice but is significantly less than in Tcra^tm1Mom homozygotes

colitis ( J:135597 )

• the colitis associated with Tcra^tm1Mom homozygotes is less severe in these mice with lower histological disease score and no anorectal prolapse

cellular

impaired macrophage chemotaxis ( J:135597 )

• less macrophages are found in the lamina propia of the gut during colitis than in Tcra^tm1Mom homozygotes

Allelic Composition	Rr100^tm2.1Welm/Rr100^tm2.1Welm Tcra^tm1Mom/Tcra^tm1Mom
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr100^tm2.1Welm mutation (0 available); any Rr100 mutation (0 available)
Tcra^tm1Mom mutation (6 available); any Tcra mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal T cell morphology ( J:113136 )

• mice have population of abnormal "CD8-negative" SP thymocytes

immune system

abnormal T cell morphology ( J:113136 )

• mice have population of abnormal "CD8-negative" SP thymocytes

Allelic Composition	Tcra^tm1Mom/Tcra^tm1Mom Trex1^tm1Tld/Trex1^tm1Tld
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra^tm1Mom mutation (6 available); any Tcra mutation (98 available)
Trex1^tm1Tld mutation (2 available); any Trex1 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:181257 )

N	• mortality observed in either single homozygote is rescued

immune system

immune system phenotype ( J:181257 )

N	• autoimmune pathology observed in Trex1^tm1Tld homozygotes is rescued

increased inflammatory response ( J:181257 )

• as in Tcra^tm1Mom homozygotes

colitis ( J:181257 )

• inflammatory bowel disease as in Tcra^tm1Mom homozygotes

myositis ( J:181257 )

• as in Tcra^tm1Mom homozygotes

skin inflammation ( J:181257 )

• as in Tcra^tm1Mom homozygotes

digestive/alimentary system

colitis ( J:181257 )

• inflammatory bowel disease as in Tcra^tm1Mom homozygotes

integument

skin inflammation ( J:181257 )

• as in Tcra^tm1Mom homozygotes

muscle

myositis ( J:181257 )

• as in Tcra^tm1Mom homozygotes

Allelic Composition	Tcra^tm1Mom/Tcra^tm1Mom Tg(CD19-Tnfsf7)#Rvl/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra^tm1Mom mutation (6 available); any Tcra mutation (98 available)
Tg(CD19-Tnfsf7)#Rvl mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

absent T cells ( J:88620 )

• spleens lack T cells

immune system

absent T cells ( J:88620 )

• spleens lack T cells

Allelic Composition	Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} H2^d/H2^d Ptcra^tm1Vbo/Ptcra^tm1Vbo Tg(Tcrb)93Vbo/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^d mutation (23 available); any H2 mutation (280 available)
Ptcra^tm1Vbo mutation (0 available); any Ptcra mutation (16 available)
Tcra/Tcrd^{tm1.1(Tcra)Rsky} mutation (0 available); any Tcrd mutation (15 available)
Tcra^tm1Mom mutation (6 available); any Tcra mutation (98 available)
Tg(Tcrb)93Vbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block in Ptcra^tm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

immune system

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block in Ptcra^tm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

endocrine/exocrine glands

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

Allelic Composition	H2^b/H2^b Ptcra^tm1Vbo/Ptcra^tm1Vbo Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} Tg(Tcrb)93Vbo/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^b mutation (28 available); any H2 mutation (280 available)
Ptcra^tm1Vbo mutation (0 available); any Ptcra mutation (16 available)
Tcra/Tcrd^{tm1.1(Tcra)Rsky} mutation (0 available); any Tcra mutation (98 available)
Tcra^tm1Mom mutation (6 available); any Tcra mutation (98 available)
Tg(Tcrb)93Vbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block in Ptcra^tm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

hematopoietic system

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block in Ptcra^tm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

endocrine/exocrine glands

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

Allelic Composition	Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} H2^b/H2^b Tg(Tcrb)93Vbo/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^b mutation (28 available); any H2 mutation (280 available)
Tcra/Tcrd^{tm1.1(Tcra)Rsky} mutation (0 available); any Tcrd mutation (15 available)
Tcra^tm1Mom mutation (6 available); any Tcra mutation (98 available)
Tg(Tcrb)93Vbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased thymocyte number ( J:131357 )

abnormal T cell differentiation ( J:81564 )

• 18% of lymph node T cells from female mice bearing H2-D^b express the HY-alpha t cell receptor chain

• the majority of T cells in male mice are HYalpha⁺ CD4^-CD8^lo or HYalpha⁺ CD4^-CD8^-

• 5 of 29 HY^- thymocytes from H2-D^b background mice have some receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient

abnormal negative T cell selection ( J:81564 )

• thymocytes from male mice on a H2-D^b background that express the HY receptor are CD69⁺ and undergoing apoptosis due to negative selection

abnormal double-negative T cell morphology ( J:131357 )

• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)

• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44

• the percentage of DN cells in the thymus is increased

abnormal double-positive T cell morphology ( J:81564 )

• female mice on a H2-D^b background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene

• the majority of these DP thymocytes do not carry the HY TCR

• male mice on a H2-D^b background have 4% the number of double positive thymocytes

decreased double-positive T cell number ( J:131357 )

immune system

decreased thymocyte number ( J:131357 )

abnormal T cell differentiation ( J:81564 )

• 18% of lymph node T cells from female mice bearing H2-D^b express the HY-alpha t cell receptor chain

• the majority of T cells in male mice are HYalpha⁺ CD4^-CD8^lo or HYalpha⁺ CD4^-CD8^-

• 5 of 29 HY^- thymocytes from H2-D^b background mice have some receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient

abnormal negative T cell selection ( J:81564 )

• thymocytes from male mice on a H2-D^b background that express the HY receptor are CD69⁺ and undergoing apoptosis due to negative selection

abnormal double-negative T cell morphology ( J:131357 )

• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)

• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44

• the percentage of DN cells in the thymus is increased

abnormal double-positive T cell morphology ( J:81564 )

• female mice on a H2-D^b background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene

• the majority of these DP thymocytes do not carry the HY TCR

• male mice on a H2-D^b background have 4% the number of double positive thymocytes

decreased double-positive T cell number ( J:131357 )

endocrine/exocrine glands

decreased thymocyte number ( J:131357 )

Allelic Composition	H2^b/H2^b Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} Tg(Tcrb)93Vbo/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^b mutation (28 available); any H2 mutation (280 available)
Tcra/Tcrd^{tm1.1(Tcra)Rsky} mutation (0 available); any Tcra mutation (98 available)
Tcra^tm1Mom mutation (6 available); any Tcra mutation (98 available)
Tg(Tcrb)93Vbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte number ( J:131357 )

• thymocyte number is reduced by about half compared to controls

abnormal T cell differentiation ( J:81564 )

• 18% of lymph node T cells from female mice bearing H2-D^b express the HY-alpha t cell receptor chain

• the majority of T cells in male mice are HYalpha⁺ CD4^-CD8^lo or HYalpha⁺ CD4^-CD8^-

• 5 of 29 thymocytes from H2-D^b background mice not expressing the HY TCR show evidence of receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient

abnormal negative T cell selection ( J:81564 )

• thymocytes from male mice on a H2-D^b background that express the HY receptor are CD69⁺ and undergoing apoptosis due to negative selection

abnormal double-negative T cell morphology ( J:131357 )

• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)

• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44

• the percentage of DN cells in the thymus is increased

abnormal double-positive T cell morphology ( J:81564 )

• female mice on a H2-D^b background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene

• the majority of these DP thymocytes do not carry the HY TCR

• male mice on a H2-D^b background have 4% the number of double positive thymocytes

decreased double-positive T cell number ( J:131357 )

• the percentage of DP thymocytes is decreased in these mice

hematopoietic system

decreased thymocyte number ( J:131357 )

• thymocyte number is reduced by about half compared to controls

abnormal T cell differentiation ( J:81564 )

• 18% of lymph node T cells from female mice bearing H2-D^b express the HY-alpha t cell receptor chain

• the majority of T cells in male mice are HYalpha⁺ CD4^-CD8^lo or HYalpha⁺ CD4^-CD8^-

abnormal negative T cell selection ( J:81564 )

• thymocytes from male mice on a H2-D^b background that express the HY receptor are CD69⁺ and undergoing apoptosis due to negative selection

abnormal double-negative T cell morphology ( J:131357 )

• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)

• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44

• the percentage of DN cells in the thymus is increased

abnormal double-positive T cell morphology ( J:81564 )

• female mice on a H2-D^b background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene

• the majority of these DP thymocytes do not carry the HY TCR

• male mice on a H2-D^b background have 4% the number of double positive thymocytes

decreased double-positive T cell number ( J:131357 )

• the percentage of DP thymocytes is decreased in these mice

endocrine/exocrine glands

decreased thymocyte number ( J:131357 )

• thymocyte number is reduced by about half compared to controls

Allelic Composition	Tcra^tm1Mom/Tcra^tm1Mom Tg(Lck-Akt1*E40K)E-3Pnt/0
Genetic Background	involves: 129S2/SvPas * C3H/He * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra^tm1Mom mutation (6 available); any Tcra mutation (98 available)
Tg(Lck-Akt1*E40K)E-3Pnt mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

arrested T cell differentiation ( J:135903 )

• T cell development is arrested at the double positive stage

• the presence of the transgene does not overcome this block the presence of the transgene does not overcome this block the presence of the transgene does not overcome this block

hematopoietic system

arrested T cell differentiation ( J:135903 )

• T cell development is arrested at the double positive stage

• the presence of the transgene does not overcome this block the presence of the transgene does not overcome this block the presence of the transgene does not overcome this block

Allelic Composition	Tcra^tm1Mom/Tcra^tm1Mom Tg(TcraAV19AJ33)1Shima/?
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra^tm1Mom mutation (6 available); any Tcra mutation (98 available)
Tg(TcraAV19AJ33)1Shima mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal NK T cell morphology ( J:140924 )

• the only T cells present in the mice express a transgenic alpha chain that is associated with NK T cells

• Valpha 14 NK T cells are not present in these mice

• 30% of mononuclear cells in the liver are transgenic NK T cells

abnormal NK T cell physiology ( J:140924 )

• NK T cells respond to alpha-GalCer, a ligand normally associated with Valpha14 NK T cell activation

• the NK T cells are also reactive to alpha-ManCer

hematopoietic system

abnormal NK T cell morphology ( J:140924 )

• the only T cells present in the mice express a transgenic alpha chain that is associated with NK T cells

• Valpha 14 NK T cells are not present in these mice

• 30% of mononuclear cells in the liver are transgenic NK T cells

abnormal NK T cell physiology ( J:140924 )

• NK T cells respond to alpha-GalCer, a ligand normally associated with Valpha14 NK T cell activation

• the NK T cells are also reactive to alpha-ManCer

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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