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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ngfrtm1Jae
targeted mutation 1, Rudolf Jaenisch
MGI:1857226
Summary 20 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ngfrtm1Jae/Ngfrtm1Jae B6.129S4-Ngfrtm1Jae MGI:3044432
hm2
Ngfrtm1Jae/Ngfrtm1Jae B6.129S4-Ngfrtm1Jae/J MGI:3702322
hm3
Ngfrtm1Jae/Ngfrtm1Jae C;129S-Ngfrtm1Jae/J MGI:2175146
hm4
Ngfrtm1Jae/Ngfrtm1Jae involves: 129 * BALB/c MGI:3531406
hm5
Ngfrtm1Jae/Ngfrtm1Jae involves: 129S1/Sv * 129S4/SvJae MGI:3835511
hm6
Ngfrtm1Jae/Ngfrtm1Jae involves: 129S4/SvJae MGI:3770685
hm7
Ngfrtm1Jae/Ngfrtm1Jae involves: 129S4/SvJae * BALB/c MGI:3770677
hm8
Ngfrtm1Jae/Ngfrtm1Jae involves: 129S4/SvJae * C57BL/6 MGI:3809496
hm9
Ngfrtm1Jae/Ngfrtm1Jae involves: 129S4/SvJae * C57BL/6J MGI:3719110
ht10
Ngfrtm1Jae/Ngfr+ B6.129S4-Ngfrtm1Jae MGI:3770684
cx11
Ngftm1.1Blhe/Ngf+
Ngfrtm1Jae/Ngfrtm1Jae
B6.Cg-Ngftm1.1Blhe Ngfrtm1Jae MGI:5461512
cx12
Ngfrtm1Jae/Ngfrtm1Jae
Plgtm1Jld/Plgtm1Jld
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:3770689
cx13
Ngfrtm1Jae/Ngfrtm1Jae
Ntf5tm1Jae/Ntf5tm1Jae
involves: 129S4/SvJae MGI:3770686
cx14
Ngfrtm1Jae/Ngfrtm1Jae
Ntf3tm1Jae/Ntf3tm1Jae
involves: 129S4/SvJae * BALB/c MGI:3770678
cx15
Ngfrtm1Jae/Ngfrtm1Jae
Ntf3tm1Jae/Ntf3+
involves: 129S4/SvJae * BALB/c MGI:3770676
cx16
Ngfrtm1Jae/Ngfr+
Omptm1(tTA)Gogo/Omp+
Tg(tetO-tetX,lacZ)2Gogo/?
involves: 129S4/SvJae * C57BL/6 MGI:3723452
cx17
Ngfrtm1Jae/Ngfrtm1Jae
Omptm1(tTA)Gogo/Omp+
Tg(tetO-tetX,lacZ)2Gogo/?
involves: 129S4/SvJae * C57BL/6 MGI:3723445
cx18
Ngfrtm1Jae/Ngfrtm1Jae
Omptm1(tTA)Gogo/Omp+
Tg(tetO-tetX,lacZ)1Gogo/?
involves: 129S4/SvJae * C57BL/6 MGI:3723454
cx19
Ngfrtm1Jae/Ngfrtm1Jae
Sema3atm1Mcf/Sema3a+
involves: 129S4/SvJae * C57BL/6 MGI:3770681
cx20
Ngfrtm1Jae/Ngfrtm1Jae
Sema3atm1Mcf/Sema3atm1Mcf
involves: 129S4/SvJae * C57BL/6 MGI:3770682


Genotype
MGI:3044432
hm1
Allelic
Composition
Ngfrtm1Jae/Ngfrtm1Jae
Genetic
Background
B6.129S4-Ngfrtm1Jae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation (2 available); any Ngfr mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• areas of the epithelium of the tongue lack innervation and the filiform papillae are sparsely innervated
• the axons in the tongue display reduced branching and smaller terminal arbors
• like wild-type neurons, cultured superior cervical ganglion neurons are resistant to apoptosis induced by pro-NGF and pro-BDNF
• the number of sympathetic neurons is increased 33% at P4 and 39% at P15 compared to in wild-type mice
• at 60 weeks sympathetic neuron cell bodies are 25% smaller than in wild-type mice
• unlike in wild-type mice, superior cervical ganglion are protected from age-related apoptosis
• peripheral nerves in the hindlimb, forelimb, and trigeminal ganglia are severely stunted compared to in wild-type mice
• growth cones from dorsal root ganglion neurons are more sensitive to Sema3A repulsion than wild-type neurons
• when treated with 15 pM Sema3A outgrowth rate inhibition is increased (15 um per hour compared to 35 um per hour for wild-type neurons)
• however, increased sensitivity to Sema3A repulsion is alleviated in a double heterozygote cross of Ngfr and Sema3A
• innervation of the somatosensory prominences is reduced
• innervation of the fungiform papillae are reduced
• at P0 there are 35% fewer geniculate ganglion neurons that supply taste neurons to the fungiform papillae in homozygotes compared to wild-type mice
• the number of sympathetic neurons is increased 33% at P4 and 39% at P15 compared to in wild-type mice
• after 2 weeks of light exposure, the number of rows of photoreceptors is 4.6+/-0.31 rows compared to 2.3+/-0.25 in wild-type mice and 21.2+/-0.25 in homozygous mice
• after 3 weeks of light exposure, the number of rows of photoreceptors is 3.0+/-0.41 rows compared to 1.5+/-0.24 in wild-type mice and 0.9+/-0.28 in homozygous mice

digestive/alimentary system
• at P7 the gustatory epithelium of the vallate trench is thicker than normal blocking direct access of the ectopic tastse buds in the trench to taste solutions
• the vallate papilla is deformed and small in neonatal mutants
• at P7 the vallate trench is only 60% as deep as in wild-type mice

cardiovascular system
• after 3 weeks in culture hepatic stellate cells are in a quiescent state and are less differentiated than in wild-type mice
• formation of neointimal lesions is enhanced 2 and 4 weeks after ligation compared to in wild-type mice such that there is a 2- to 4-fold increase in intimal to medial ratio at 500 um and 1.0 mm proximal to the ligation
• however, infiltration of inflammatory cells is normal
• apoptosis in neointimal lesions is decreased by 60% to 70%

taste/olfaction
• at P7 homozygous mice have 26% fewer vallate taste buds than wild-type mice
• homozygous mice have fewer fungiform taste buds than wild-type mice

immune system
• after 3 weeks in culture hepatic stellate cells are in a quiescent state and are less differentiated than in wild-type mice
• mice have an increased risk of developing severe experimental autoimmune encephalomyelitis compared to wild-type mice
• B220+ B cells make up 6% of cells in the inflammatory cuffs compared to 15% in wild-type mice immunized with MOG35-55
• the population of Iba-1+ cells in the inflammatory cuffs is reduced by 10% compared to in wild-type mice immunized with MOG35-55
• polymorphonuclear cells are reduced by half compared to in wild-type mice immunized with MOG35-55
• microglial/macrophage and neutrophil numbers in the inflammatory infiltrate are reduced 68% to 40% while the size of the inflitratory cuffs is normal or even larger than in wild-type mice
• however, the number of double-positive (monocyte) cells is normal
• mice display considerable infiltration of fibronectin into the spinal cord parenchyma

homeostasis/metabolism
• formation of neointimal lesions is enhanced 2 and 4 weeks after ligation compared to in wild-type mice such that there is a 2- to 4-fold increase in intimal to medial ratio at 500 um and 1.0 mm proximal to the ligation
• however, infiltration of inflammatory cells is normal
• apoptosis in neointimal lesions is decreased by 60% to 70%

liver/biliary system
• after 3 weeks in culture hepatic stellate cells are in a quiescent state and are less differentiated than in wild-type mice

vision/eye
• after 2 weeks of light exposure, the number of rows of photoreceptors is 4.6+/-0.31 rows compared to 2.3+/-0.25 in wild-type mice and 21.2+/-0.25 in homozygous mice
• after 3 weeks of light exposure, the number of rows of photoreceptors is 3.0+/-0.41 rows compared to 1.5+/-0.24 in wild-type mice and 0.9+/-0.28 in homozygous mice

hematopoietic system
• after 3 weeks in culture hepatic stellate cells are in a quiescent state and are less differentiated than in wild-type mice

craniofacial
• at P7 the gustatory epithelium of the vallate trench is thicker than normal blocking direct access of the ectopic tastse buds in the trench to taste solutions
• the vallate papilla is deformed and small in neonatal mutants
• at P7 the vallate trench is only 60% as deep as in wild-type mice

cellular
• peripheral nerves in the hindlimb, forelimb, and trigeminal ganglia are severely stunted compared to in wild-type mice
• growth cones from dorsal root ganglion neurons are more sensitive to Sema3A repulsion than wild-type neurons
• when treated with 15 pM Sema3A outgrowth rate inhibition is increased (15 um per hour compared to 35 um per hour for wild-type neurons)
• however, increased sensitivity to Sema3A repulsion is alleviated in a double heterozygote cross of Ngfr and Sema3A

growth/size/body
• at P7 the gustatory epithelium of the vallate trench is thicker than normal blocking direct access of the ectopic tastse buds in the trench to taste solutions
• the vallate papilla is deformed and small in neonatal mutants
• at P7 the vallate trench is only 60% as deep as in wild-type mice




Genotype
MGI:3702322
hm2
Allelic
Composition
Ngfrtm1Jae/Ngfrtm1Jae
Genetic
Background
B6.129S4-Ngfrtm1Jae/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation (2 available); any Ngfr mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Reduced infarct size in Ngfrtm1Jae/Ngfrtm1Jae mice after cardiac ischemia-reperfusion surgery

hearing/vestibular/ear
• by 6 months, male homozygotes exhibit absence or damage of cochlear HCs in both the basal and upper turns
• however, IHCs are still present and morphologically normal at 4 months, suggesting that SGN's dendrites connecting the IHCs are damaged earlier than IHCs
• at 1 month of age, male homozygotes exhibit a grossly normal organ of the Corti, except for a slight reduction in the number of SGNs
• by 6 months, male homozygotes show complete degeneration of the organ of Corti in the basal turns
• at 4 months of age, male homozygotes exhibit a significant elevation (>33 dB SPL) in click-evoked ABR thresholds relative to wild-type males
• at 6 months and 1 year, male homozygotes continue to display significant increases in ABR thresholds relative to age-matched wild-type males (100 and 126 dB SPL, respectively)
• however, no significant differences in click-evoked ABR thresholds are observed at 1 month, consistent with a normal cochlear structure at this age
• starting at 4 months, male homozygotes display an age-related progressive hearing loss relative to age-matched wild-type males
• by 1 year of age, homozygotes are unresponsive to click stimuli at the maximum level (136 dB SPL)
• male homozygotes show progressive hearing loss at 4 months, when both SGN degeneration and hair cell loss are observed in the basal cochlear turn

nervous system
• by 6 months, male homozygotes exhibit absence or damage of cochlear HCs in both the basal and upper turns
• however, IHCs are still present and morphologically normal at 4 months, suggesting that SGN's dendrites connecting the IHCs are damaged earlier than IHCs
• starting at 1 month, male homozygotes show a slight (15.7%) but progressive loss of SGNs from the basal to the apical cochlear turns
• at 4 months, male homozygotes display significant SGN degeneration in the basal cochlear turn and swelling of the afferent dendrites below IHCs in the middle turns
• by 6 months, the density of SGNs is significantly reduced in the middle and basal turns, with a 59.8% loss of SGNs in the most basal turns

cardiovascular system
• 10 days after myocardial ischemic/reperfusion injury

homeostasis/metabolism
• 10 days after myocardial ischemic/reperfusion injury




Genotype
MGI:2175146
hm3
Allelic
Composition
Ngfrtm1Jae/Ngfrtm1Jae
Genetic
Background
C;129S-Ngfrtm1Jae/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation (2 available); any Ngfr mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• reduced levels of neuronal cell death

cellular
• reduced levels of neuronal cell death




Genotype
MGI:3531406
hm4
Allelic
Composition
Ngfrtm1Jae/Ngfrtm1Jae
Genetic
Background
involves: 129 * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation (2 available); any Ngfr mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• reduced inhibition by myelin of neurite outgrowth from dorsal root ganglion neurons, but not cerebellar neurons, compared to heterozygous controls, indicating that mutant neurons are much less sensitive to myelin
• reduced inhibition by Nogo-66 (Rtn4) peptide of neurite outgrowth from P7 cerebellar neurons compared with heterozygous controls, however homozygotes did not show enhanced regeneration of corticospinal tract axons in comparison with wild-type after spinal dorsal hemisection

cellular
• reduced inhibition by myelin of neurite outgrowth from dorsal root ganglion neurons, but not cerebellar neurons, compared to heterozygous controls, indicating that mutant neurons are much less sensitive to myelin
• reduced inhibition by Nogo-66 (Rtn4) peptide of neurite outgrowth from P7 cerebellar neurons compared with heterozygous controls, however homozygotes did not show enhanced regeneration of corticospinal tract axons in comparison with wild-type after spinal dorsal hemisection




Genotype
MGI:3835511
hm5
Allelic
Composition
Ngfrtm1Jae/Ngfrtm1Jae
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation (2 available); any Ngfr mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the nasal domain of retinal axon termination zone is expanded anteriorly and in some cases evidence of ectopic arborization in non-labelled axons unlike in wild-type mice
• at P8, the termination zone of retinal ganglion cell axons in the superior colliculus is shifted anteriorly compared to in wild-type mice
• the nasal domain of retinal axon termination zone is expanded anteriorly and in some cases evidence of ectopic arborization in non-labelled axons unlike in wild-type mice
• at P8, the termination zone of retinal ganglion cell axons in the superior colliculus is shifted anteriorly compared to in wild-type mice

vision/eye
• the nasal domain of retinal axon termination zone is expanded anteriorly and in some cases evidence of ectopic arborization in non-labelled axons unlike in wild-type mice
• at P8, the termination zone of retinal ganglion cell axons in the superior colliculus is shifted anteriorly compared to in wild-type mice




Genotype
MGI:3770685
hm6
Allelic
Composition
Ngfrtm1Jae/Ngfrtm1Jae
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation (2 available); any Ngfr mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at E12 and E14, neuron apoptosis is reduced 72% and 70%, respectively, compared to in wild-type mice
• nearly all neurons cultured with NT4 survive unlike wild-type neurons
• when given the choice between strips that contain Eph47-Fc or Fc, retinal axons fail to avoid EPHA7-Fc stripes or exhibit a preference for the Fc stripes unlike wild-type axons
• however, avoidance of stripes with EPHA5-Fc is normal
• however, total area of the superior colliculus is normal
• the nasal domain of retinal axon termination zone is expanded anteriorly and in some cases evidence of ectopic arborization in non-labelled axons unlike in wild-type mice
• at P8, the termination zone of retinal ganglion cell axons in the superior colliculus is shifted anteriorly compared to in wild-type mice
• absence of sensory innervation to pineal and sweat glands
• increased size of cholinergic forebrain neurons
• 50% of mice exhibit ectopic branches and arbors along the anterior posterior length of the nasal RGC axons in the superior colliculus unlike in wild-type mice
• the nasal domain of retinal axon termination zone is expanded anteriorly and in some cases evidence of ectopic arborization in non-labelled axons unlike in wild-type mice
• at P8, the termination zone of retinal ganglion cell axons in the superior colliculus is shifted anteriorly compared to in wild-type mice
• ophthalmic branch of the trigeminal ganglion is severely truncated at E12.5

behavior/neurological
• spatial learning is improved compared to in wild-type mice without deterioration with age

vision/eye
• 50% of mice exhibit ectopic branches and arbors along the anterior posterior length of the nasal RGC axons in the superior colliculus unlike in wild-type mice
• the nasal domain of retinal axon termination zone is expanded anteriorly and in some cases evidence of ectopic arborization in non-labelled axons unlike in wild-type mice
• at P8, the termination zone of retinal ganglion cell axons in the superior colliculus is shifted anteriorly compared to in wild-type mice
• mice subjected to intraocular injection of the pro form of nerve growth factor are protected from induced retinal ganglion cell death

homeostasis/metabolism
• the pro form of nerve growth factor fails to induce TNF expression in retinas

immune system
• the pro form of nerve growth factor fails to induce TNF expression in retinas

cellular
• at E12 and E14, neuron apoptosis is reduced 72% and 70%, respectively, compared to in wild-type mice
• nearly all neurons cultured with NT4 survive unlike wild-type neurons
• when given the choice between strips that contain Eph47-Fc or Fc, retinal axons fail to avoid EPHA7-Fc stripes or exhibit a preference for the Fc stripes unlike wild-type axons
• however, avoidance of stripes with EPHA5-Fc is normal




Genotype
MGI:3770677
hm7
Allelic
Composition
Ngfrtm1Jae/Ngfrtm1Jae
Genetic
Background
involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation (2 available); any Ngfr mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• spindle density in the soleus, but no the medial gastrocnemius, plantaris and lumbrical muscles, is reduced 50% compared to in wild-type mice
• at 3 to 5 months, Pde6a+ pulpal neurons are decreased (J:42087)
• the dermis of fore- and hindlimb paws either lacks or have reduced numbers of Pde6a+ sensory fibers and small-diameter nerves are absent (J:43748)
• only a few single fibers are present in the subepidermis and none are detected in the epidermis of fore- and hindlimb paws (J:43748)
• reduced innervation is not restricted to hairless patches (J:43748)
• however, sympathetic innervation of the iris and salivary glands is normal (J:43748)
• mice exhibit a loss of myelinated fibers in the dorsal root ganglion
• mice exhibit a 50% loss of proprioreceptive neurons in L4 of the dorsal root ganglion
• at E14.5, L4 is smaller than in wild-type mice due to a 7.5-fold increase in apoptosis

skeleton
• increased signs of wear on molars
• mandibular molar occlusal facets are longer than in wild-type mice
• maxillary molar crown height is reduced by 15%
• however, full height of teeth is normal

muscle
• muscles exhibit fewer myelinated fibers than in wild-type mice (36+/-2 compared to 76+/-2 in wild-type mice)
• spindle density in the soleus, but no the medial gastrocnemius, plantaris and lumbrical muscles, is reduced 50% compared to in wild-type mice

behavior/neurological
• prolonged latency in hot plate test

homeostasis/metabolism
• at 4 months of age, mice exbihit edema in the fore- and hindlimb paws

limbs/digits/tail
• at 4 months of age, fore- and hindlimb paws become edematous and develop severe ulcers
• ulcers progress more proximally
• ulcers are complicated by secondary infections that result in the lose of toenails and hair
• epidermis and epidermal structures are lost from areas affected by ulcers
• excessive epidermal proliferation is present at the edges of ulcers

renal/urinary system
N
• unlike in studies using p75NGFR oligonucleotide knockdown, kidney function is normal

craniofacial
• the height of the oral cavity is reduced
• increased signs of wear on molars
• mandibular molar occlusal facets are longer than in wild-type mice
• maxillary molar crown height is reduced by 15%
• however, full height of teeth is normal

integument
• loss of follicles, at distal extremities, progressive to more proximal regions

growth/size/body
• the height of the oral cavity is reduced
• increased signs of wear on molars
• mandibular molar occlusal facets are longer than in wild-type mice
• maxillary molar crown height is reduced by 15%
• however, full height of teeth is normal




Genotype
MGI:3809496
hm8
Allelic
Composition
Ngfrtm1Jae/Ngfrtm1Jae
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation (2 available); any Ngfr mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• axons of mutant neurons grown in vitro in the presence of NGF grow equally well regardless if they are stimulated or not in contrast to wild-type neurons where stimulated axons out compete non-stimulated axons
• this lack of growth disadvantage in non-stimulated axons is due to less axon degeneration than occurs to wild-type neurons
• sympathetic neurons of the superior cervical ganglion (SCG) have improper pruning of axons from neurons that reach into both eye compartments
• SCG neurons in wild-type mice reduce through axon pruning the number of neurons projecting to both eyes from 78% at p20 to 20% at p50
• mutant mice have a similar percentage of SCG neurons that connect to both eyes at P20 but this percentage does not decrease with age
• at p35 where SCG neurons are actively pruning exons in wild-type mice, mutant mice have significantly less degenerating SCG axons than in wild-type mice

cellular
• axons of mutant neurons grown in vitro in the presence of NGF grow equally well regardless if they are stimulated or not in contrast to wild-type neurons where stimulated axons out compete non-stimulated axons
• this lack of growth disadvantage in non-stimulated axons is due to less axon degeneration than occurs to wild-type neurons
• sympathetic neurons of the superior cervical ganglion (SCG) have improper pruning of axons from neurons that reach into both eye compartments
• SCG neurons in wild-type mice reduce through axon pruning the number of neurons projecting to both eyes from 78% at p20 to 20% at p50
• mutant mice have a similar percentage of SCG neurons that connect to both eyes at P20 but this percentage does not decrease with age
• at p35 where SCG neurons are actively pruning exons in wild-type mice, mutant mice have significantly less degenerating SCG axons than in wild-type mice




Genotype
MGI:3719110
hm9
Allelic
Composition
Ngfrtm1Jae/Ngfrtm1Jae
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation (2 available); any Ngfr mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the number of motor neurons in tibial nerve is reduced
• motor axonal regeneration is increased in the tibial nerve cross-suture




Genotype
MGI:3770684
ht10
Allelic
Composition
Ngfrtm1Jae/Ngfr+
Genetic
Background
B6.129S4-Ngfrtm1Jae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation (2 available); any Ngfr mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• nerve coverage is less than in wild-type mice but not as severely reduced as in Ngfrtm1Jae homozygotes
• neurons exhibit an intermediate effect to Sema3a repulsion that is more sensitive than wild-type neurons but not as sensitive as Ngfrtm1Jae homozygotes

respiratory system
• unlike in wild-type mice, no airway hyper-responsiveness was observed following exposure to Ach and ovalbumin (50% brionchiorestriction occurs at 580 ug per kg for Ach and 586 ug per kg ovalbulmin compared to 552 ug per kg Ach and 62.5 ug per kg ovalbumin for wild-type mice)
• total leukocytes, eosinophils and lymphocytes do not increase as in wild-type following exposure to provocation agent
• unlike in exposed wild-type mice, no pulmonary eosinophilic inflammation is observed
• unlike in exposed wild-type mice IL-4 and IL-5 production is not increased
• while IgE levels increase following exposure to provocation they do not increase as much as in wild-type mice
• however, interferon-gamma production following exposure to provocation agent is normal

cellular
• nerve coverage is less than in wild-type mice but not as severely reduced as in Ngfrtm1Jae homozygotes
• neurons exhibit an intermediate effect to Sema3a repulsion that is more sensitive than wild-type neurons but not as sensitive as Ngfrtm1Jae homozygotes




Genotype
MGI:5461512
cx11
Allelic
Composition
Ngftm1.1Blhe/Ngf+
Ngfrtm1Jae/Ngfrtm1Jae
Genetic
Background
B6.Cg-Ngftm1.1Blhe Ngfrtm1Jae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation (2 available); any Ngfr mutation (22 available)
Ngftm1.1Blhe mutation (0 available); any Ngf mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Adult Ngftm1.1Blhe/Ngf+ mice exhibit dilated cardiomyopathy and fibrosis and this phentoype is rescued in Ngfrtm1Jae/Ngfrtm1Jae Ngftm1.1Blhe/Ngf+ mice

cardiovascular system
N
• unlike Ngftm1.1Blhe heterozygotes, mice do not exhibit ventricular dilation, fibrosis cardiac hypocontractility or premature death




Genotype
MGI:3770689
cx12
Allelic
Composition
Ngfrtm1Jae/Ngfrtm1Jae
Plgtm1Jld/Plgtm1Jld
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation (2 available); any Ngfr mutation (22 available)
Plgtm1Jld mutation (3 available); any Plg mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival is 2.5 months

liver/biliary system
• mice exhibit apoptosis in the liver that is restricted to hepatocytes
• mice exhibit prominent liver lesions at 10 weeks with large necrotic lesions
• the number of proliferating hepatocyte is decreased (74.2+/-9.1 compare to 95.2+/-3.7 in wild-type mice)

growth/size/body
• at 5 weeks of age

cellular
• mice exhibit apoptosis in the liver that is restricted to hepatocytes
• mice exhibit prominent liver lesions at 10 weeks with large necrotic lesions
• the number of proliferating hepatocyte is decreased (74.2+/-9.1 compare to 95.2+/-3.7 in wild-type mice)




Genotype
MGI:3770686
cx13
Allelic
Composition
Ngfrtm1Jae/Ngfrtm1Jae
Ntf5tm1Jae/Ntf5tm1Jae
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation (2 available); any Ngfr mutation (22 available)
Ntf5tm1Jae mutation (1 available); any Ntf5 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at E12 and E14, neuron apoptosis is reduced 79% and 63%, respectively, compared to in wild-type mice

cellular
• at E12 and E14, neuron apoptosis is reduced 79% and 63%, respectively, compared to in wild-type mice




Genotype
MGI:3770678
cx14
Allelic
Composition
Ngfrtm1Jae/Ngfrtm1Jae
Ntf3tm1Jae/Ntf3tm1Jae
Genetic
Background
involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation (2 available); any Ngfr mutation (22 available)
Ntf3tm1Jae mutation (2 available); any Ntf3 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3770676
cx15
Allelic
Composition
Ngfrtm1Jae/Ngfrtm1Jae
Ntf3tm1Jae/Ntf3+
Genetic
Background
involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation (2 available); any Ngfr mutation (22 available)
Ntf3tm1Jae mutation (2 available); any Ntf3 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• few mice survive past 3 weeks of age

nervous system
• spindle density in the soleus, the medial gastrocnemius, plantaris and lumbrical muscles is reduced 50% compared to in wild-type mice
• 31% of soleus muscles are devoid of muscle spindles
• mice exhibit a 78% loss in sensory neurons in the dorsal root ganglion
• mice exhibit a loss of 82% myelinated fibers in the dorsal root ganglion
• mice exhibit a loss of 75% of dorsal root ganglion neurons
• at E14.5, Ia neuron projections in the dorsal root ganglion are severely reduced
• mice exhibit a 90% loss of proprioreceptive neurons in the dorsal root ganglion
• at E14.5, L4 is smaller than in wild-type mice due to a 12.1-fold increase in apoptosis

behavior/neurological
• mice exhibit ataxia during the first two weeks after birth but not during adulthood
• mice exhibit dystonia during the first two weeks after birth but not during adulthood
• mice exhibit an unstable gait and mild posturing of extremities during the first two weeks after birth but not during adulthood

muscle
• mice exhibit dystonia during the first two weeks after birth but not during adulthood
• muscles exhibit fewer myelinated fibers than in wild-type mice (26+/-2 compared to 76+/-2 in wild-type mice)
• spindle density in the soleus, the medial gastrocnemius, plantaris and lumbrical muscles is reduced 50% compared to in wild-type mice
• 31% of soleus muscles are devoid of muscle spindles
• mice that survive longer than 3 weeks exhibit flexor spasms and uplifting of hindlimbs during weeks 3 to 4

growth/size/body
• mice weight 10% to 30% less than wild-type mice




Genotype
MGI:3723452
cx16
Allelic
Composition
Ngfrtm1Jae/Ngfr+
Omptm1(tTA)Gogo/Omp+
Tg(tetO-tetX,lacZ)2Gogo/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation (2 available); any Ngfr mutation (22 available)
Omptm1(tTA)Gogo mutation (1 available); any Omp mutation (20 available)
Tg(tetO-tetX,lacZ)2Gogo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• following doxycycline treatment, terminal-arbor complexity is partially rescued (4 branches per axon compared to 1.96+/-0.17 in Tg(tetO-tetX,lacZ)2Gogo Omptm1(tTA)Gogo mice and 6.6+/-0.19 in wild-type mice)




Genotype
MGI:3723445
cx17
Allelic
Composition
Ngfrtm1Jae/Ngfrtm1Jae
Omptm1(tTA)Gogo/Omp+
Tg(tetO-tetX,lacZ)2Gogo/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation (2 available); any Ngfr mutation (22 available)
Omptm1(tTA)Gogo mutation (1 available); any Omp mutation (20 available)
Tg(tetO-tetX,lacZ)2Gogo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• following doxycycline treatment, terminal-arbor complexity of olfactory nerves is rescued with 7 branches per axon compared to 1.96+/-0.17 in Tg(tetO-tetX,lacZ)2Gogo Omptm1(tTA)Gogo mice and 6.6+/-0.19 in wild-type mice but branching length is not restored




Genotype
MGI:3723454
cx18
Allelic
Composition
Ngfrtm1Jae/Ngfrtm1Jae
Omptm1(tTA)Gogo/Omp+
Tg(tetO-tetX,lacZ)1Gogo/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation (2 available); any Ngfr mutation (22 available)
Omptm1(tTA)Gogo mutation (1 available); any Omp mutation (20 available)
Tg(tetO-tetX,lacZ)1Gogo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the positive effect of global presynaptic inactinity on the total branch length is somewhat attenuated




Genotype
MGI:3770681
cx19
Allelic
Composition
Ngfrtm1Jae/Ngfrtm1Jae
Sema3atm1Mcf/Sema3a+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation (2 available); any Ngfr mutation (22 available)
Sema3atm1Mcf mutation (0 available); any Sema3a mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• at E12.5, mice exhibit normal neuron growth that is increased 3-fold in hindlimbs, 2.7-fold in forelimbs and 4.4-fold in trigeminal ganglion compared to Ngfrtm1Jae homozygotes




Genotype
MGI:3770682
cx20
Allelic
Composition
Ngfrtm1Jae/Ngfrtm1Jae
Sema3atm1Mcf/Sema3atm1Mcf
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation (2 available); any Ngfr mutation (22 available)
Sema3atm1Mcf mutation (0 available); any Sema3a mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• peripheral axons overshot the front observed in wild-type mice
• axon density is increased 2.28-fold in hindlimbs and 1.71-fold in forelimbs compared to in wild-type mice but not as much as in Sema3atm1Mcf homozygotes (5.97-fold in hindlimbs and 3.74-fold in forelimbs)
• increased sensitivity to Sema3A repulsion in Ngfrtm1Jae homozygotes is alleviated

cellular
• peripheral axons overshot the front observed in wild-type mice
• axon density is increased 2.28-fold in hindlimbs and 1.71-fold in forelimbs compared to in wild-type mice but not as much as in Sema3atm1Mcf homozygotes (5.97-fold in hindlimbs and 3.74-fold in forelimbs)
• increased sensitivity to Sema3A repulsion in Ngfrtm1Jae homozygotes is alleviated





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory