Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12atm1Jm mutation
(2 available);
any
Il12a mutation
(33 available)
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immune system
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• 75 days after infection Il4 mRNA expression in CD4+ cells is 100-fold higher than in wild-type
• 75 days after infection Ifng mRNA expression in CD4+ cells is more than 50-fold lower than in wild-type
• draining lymph node cells in L. major infected mice produce significantly more IL4 compared to IFNG in contrast to wild-type mice which express more IFNG than IL4
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• do not show any delayed type hypersensitivity response to application of Leishmania antigen to the uninfected footpad 41 days after initial infection with L. major
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• develop large lesions unlike wild-type 129S1/Sv mice after infection with Leishmania major
• 75 days after infection with L. major parasite numbers in the draining lymph nodes are increased 80-fold compared to wild-type mice
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hematopoietic system
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• 75 days after infection Il4 mRNA expression in CD4+ cells is 100-fold higher than in wild-type
• 75 days after infection Ifng mRNA expression in CD4+ cells is more than 50-fold lower than in wild-type
• draining lymph node cells in L. major infected mice produce significantly more IL4 compared to IFNG in contrast to wild-type mice which express more IFNG than IL4
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12atm1Jm mutation
(2 available);
any
Il12a mutation
(33 available)
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immune system
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• no abnormal response to infection is detected
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12atm1Jm mutation
(2 available);
any
Il12a mutation
(33 available)
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mortality/aging
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• increase in mortality following a single dose of N-methyl-N-nitrosourea (MNU) compared to similarly treated wild-type controls
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neoplasm
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• earlier tumor appearance and increased incidence of papillomas compared to wild-type mice after treatment with DMBA and TPA in a 2 step skin carcinogenesis protocol
• however, resistance to tumor formation following intradermal challenge with with PDV squamous carcinoma cells is similar to wild-type mice
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12atm1Jm mutation
(2 available);
any
Il12a mutation
(33 available)
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immune system
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• following infection with Leishmania infantum
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hematopoietic system
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• following infection with Leishmania infantum
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12atm1Jm mutation
(2 available);
any
Il12a mutation
(33 available)
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immune system
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• NK cells in vivo make much about 7-fold less IFN-gamma in response to injections of the TLR9 agonist CpG
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hematopoietic system
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• NK cells in vivo make much about 7-fold less IFN-gamma in response to injections of the TLR9 agonist CpG
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immune system
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• following infection with Leishmania infantum
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hematopoietic system
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• following infection with Leishmania infantum
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immune system
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• splenocytes produce minimal levels of Ifng in response to mycobacterial stimulation, in contrast to response of Rag2-null cells
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• mice have higher numbers of lesions than Il2b, Rag2-null mice, but size of inflammatory foci and percentage of lung space affected is lower but lesions contain similar numbers of neutrophils
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• mice display transiently increased resistance to infection by M. tuberculosis relative to Il12b, Rag2-double null mice which die about 3 days sooner
• pulmonary bacterial loads are slightly but significantly decreased compared to Il12b, Rag2-null mutants
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respiratory system
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• mice have higher numbers of lesions than Il2b, Rag2-null mice, but size of inflammatory foci and percentage of lung space affected is lower but lesions contain similar numbers of neutrophils
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Analysis Tools