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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il7rtm1Imx
targeted mutation 1, Immunex
MGI:1857198
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il7rtm1Imx/Il7rtm1Imx B6.129S7-Il7rtm1Imx MGI:3758875
hm2
 		Il7rtm1Imx/Il7rtm1Imx involves: 129P3/J * 129S7/SvEvBrd MGI:2180131
hm3
 		Il7rtm1Imx/Il7rtm1Imx involves: 129S7/SvEvBrd MGI:3769350
cn4
 		B2mtm1Unc/B2mtm1Unc
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:5469010
cn5
 		Il4ratm1Sz/Il4ratm1Sz
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0 		involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6 MGI:5469008
cn6
 		Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0 		involves: 129S7/SvEvBrd * C57BL/6 MGI:5469007
cn7
 		Il15tm1Imx/Il15tm1Imx
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0 		involves: 129S7/SvEvBrd * C57BL/6 MGI:5469009
cn8
 		Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd4-cre)1Cwi/0 		involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 MGI:5469006
cx9
 		Il7rtm1Imx/Il7rtm1Imx
Tg(Lck-Il7r)1676Trma/? 		involves: 129S7/SvEvBrd * C57BL/6 * SJL MGI:5300162


Genotype
MGI:3758875
hm1
Allelic
Composition		 Il7rtm1Imx/Il7rtm1Imx
Genetic
Background		 B6.129S7-Il7rtm1Imx
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il7rtm1Imx mutation (4 available); any Il7r mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased thymocyte number ( J:125360 )
• thymic cellularity is severely decreased
• at all double negative stages, reduction in thymocytes is more severe than in Il7rtm1Abra homozygotes
abnormal T cell differentiation ( J:125360 )
• thymic progenitor cell number is decreased by 20-fold compared to wild-type mice
• double negative cell development is blocked at stage IV
• CD4+ and CD8+ T cell development is severely disrupted
decreased double-positive T cell number ( J:125360 )
• mice have less double positive thymocytes than Il7rtm1Abra homozygotes

immune system
decreased thymocyte number ( J:125360 )
• thymic cellularity is severely decreased
• at all double negative stages, reduction in thymocytes is more severe than in Il7rtm1Abra homozygotes
abnormal T cell differentiation ( J:125360 )
• thymic progenitor cell number is decreased by 20-fold compared to wild-type mice
• double negative cell development is blocked at stage IV
• CD4+ and CD8+ T cell development is severely disrupted
decreased double-positive T cell number ( J:125360 )
• mice have less double positive thymocytes than Il7rtm1Abra homozygotes

endocrine/exocrine glands
decreased thymocyte number ( J:125360 )
• thymic cellularity is severely decreased
• at all double negative stages, reduction in thymocytes is more severe than in Il7rtm1Abra homozygotes




Genotype
MGI:2180131
hm2
Allelic
Composition		 Il7rtm1Imx/Il7rtm1Imx
Genetic
Background		 involves: 129P3/J * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il7rtm1Imx mutation (4 available); any Il7r mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested B cell differentiation ( J:21135 )
• development arrested at the pro-B cell stage
arrested T cell differentiation ( J:21135 )
• development arrested before T cell receptor beta chain rearrangement and before CD4 and CD8 surface expression
decreased B cell number ( J:21135 )
• reduced numbers of B cells
decreased T cell number ( J:21135 )
• reduced numbers of T cells

immune system
arrested B cell differentiation ( J:21135 )
• development arrested at the pro-B cell stage
arrested T cell differentiation ( J:21135 )
• development arrested before T cell receptor beta chain rearrangement and before CD4 and CD8 surface expression
decreased B cell number ( J:21135 )
• reduced numbers of B cells
decreased T cell number ( J:21135 )
• reduced numbers of T cells
lymph node hypoplasia ( J:21135 )
• reduced peripheral and mesenteric lymph node cellularity

endocrine/exocrine glands




Genotype
MGI:3769350
hm3
Allelic
Composition		 Il7rtm1Imx/Il7rtm1Imx
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il7rtm1Imx mutation (4 available); any Il7r mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:64861 )
• at E14, thymocytes are about 100-fold lower than in heterozygous littermates
• however, differentiation of thymic progenitors into pro-T cells appears to be normal

hematopoietic system
decreased thymocyte number ( J:64861 )
• at E14, thymocytes are about 100-fold lower than in heterozygous littermates
• however, differentiation of thymic progenitors into pro-T cells appears to be normal

endocrine/exocrine glands
decreased thymocyte number ( J:64861 )
• at E14, thymocytes are about 100-fold lower than in heterozygous littermates
• however, differentiation of thymic progenitors into pro-T cells appears to be normal




Genotype
MGI:5469010
cn4
Allelic
Composition		 B2mtm1Unc/B2mtm1Unc
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (38 available); any B2m mutation (122 available)
Il7rtm1.1Asin mutation (1 available); any Il7r mutation (29 available)
Il7rtm1Imx mutation (4 available); any Il7r mutation (29 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system

hematopoietic system




Genotype
MGI:5469008
cn5
Allelic
Composition		 Il4ratm1Sz/Il4ratm1Sz
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4ratm1Sz mutation (2 available); any Il4ra mutation (41 available)
Il7rtm1.1Asin mutation (1 available); any Il7r mutation (29 available)
Il7rtm1Imx mutation (4 available); any Il7r mutation (29 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus, as in Il7rtm1.1Asin/Il7rtm1Imx Tg(Cd8a*-cre)#Asin mice

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus, as in Il7rtm1.1Asin/Il7rtm1Imx Tg(Cd8a*-cre)#Asin mice




Genotype
MGI:5469007
cn6
Allelic
Composition		 Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il7rtm1.1Asin mutation (1 available); any Il7r mutation (29 available)
Il7rtm1Imx mutation (4 available); any Il7r mutation (29 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus and periphery

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus and periphery




Genotype
MGI:5469009
cn7
Allelic
Composition		 Il15tm1Imx/Il15tm1Imx
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15tm1Imx mutation (5 available); any Il15 mutation (43 available)
Il7rtm1.1Asin mutation (1 available); any Il7r mutation (29 available)
Il7rtm1Imx mutation (4 available); any Il7r mutation (29 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus and periphery, worse than in Il7rtm1.1Asin/Il7rtm1Imx Tg(Cd8a*-cre)#Asin mice

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus and periphery, worse than in Il7rtm1.1Asin/Il7rtm1Imx Tg(Cd8a*-cre)#Asin mice




Genotype
MGI:5469006
cn8
Allelic
Composition		 Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il7rtm1.1Asin mutation (1 available); any Il7r mutation (29 available)
Il7rtm1Imx mutation (4 available); any Il7r mutation (29 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system

hematopoietic system




Genotype
MGI:5300162
cx9
Allelic
Composition		 Il7rtm1Imx/Il7rtm1Imx
Tg(Lck-Il7r)1676Trma/?
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il7rtm1Imx mutation (4 available); any Il7r mutation (29 available)
Tg(Lck-Il7r)1676Trma mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased thymocyte apoptosis ( J:66400 )
• cultured pro T-cells exhibit an increased susceptibility to apoptosis as compared to wild-type
decreased T cell proliferation ( J:66400 )
• T cell proliferation is decreased in response to anti-CD3 plus IL7, however, proliferation is similar to wild-type when induced with anti-CD3 plus IL2

hematopoietic system
increased thymocyte apoptosis ( J:66400 )
• cultured pro T-cells exhibit an increased susceptibility to apoptosis as compared to wild-type
decreased T cell proliferation ( J:66400 )
• T cell proliferation is decreased in response to anti-CD3 plus IL7, however, proliferation is similar to wild-type when induced with anti-CD3 plus IL2
decreased thymocyte number ( J:66400 )
• transgene expression restores thymic cellularity to 74% from 6% found in nontransgenic homozygous Il7rtm1Imx mice; expression is not restored on bone marrow thymocytes or CD43- B220+ B lineage cells

immune system
increased thymocyte apoptosis ( J:66400 )
• cultured pro T-cells exhibit an increased susceptibility to apoptosis as compared to wild-type
decreased T cell proliferation ( J:66400 )
• T cell proliferation is decreased in response to anti-CD3 plus IL7, however, proliferation is similar to wild-type when induced with anti-CD3 plus IL2
decreased thymocyte number ( J:66400 )
• transgene expression restores thymic cellularity to 74% from 6% found in nontransgenic homozygous Il7rtm1Imx mice; expression is not restored on bone marrow thymocytes or CD43- B220+ B lineage cells

endocrine/exocrine glands
increased thymocyte apoptosis ( J:66400 )
• cultured pro T-cells exhibit an increased susceptibility to apoptosis as compared to wild-type
decreased thymocyte number ( J:66400 )
• transgene expression restores thymic cellularity to 74% from 6% found in nontransgenic homozygous Il7rtm1Imx mice; expression is not restored on bone marrow thymocytes or CD43- B220+ B lineage cells




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory