Analysis Tools
behavior/neurological
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• mice exhibit reduced acoustic startle response amplitude compared with wild-type mice
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Allele Symbol Allele Name Allele ID |
Drd3tm1Dac targeted mutation 1, Domenico Accili MGI:1857159 |
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| Summary |
9 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit reduced acoustic startle response amplitude compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit increased entry into open arms in an elevated plus maze compared with wild-type mice
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• mice exhibit more large-reflex amplitudes for both monosynaptic 'stretch' reflex (MSR) and longer-latency reflex responses compared with wild-type mice
• mice treated with 1 or 5 um dopamine exhibit led to an increase in MSR amplitude and reflex strength unlike in similarly treated wild-type mice
• mice treated with a D3 receptor antagonist do not exhibit an increase in monosynaptic reflex strength unlike in similarly treated wild-type mice
• mice treated with D2 receptor agonists fail to exhibit a decrease in monosynaptic reflex strength compared with similarly treated wild-type mice
• mice treated with pergolide do not exhibit a difference in monosynaptic and longer-latency reflex amplitudes unlike in similarly treated wild-type mice
• mice treated with GR 103691 exhibit shorter monosynaptic than longer-latency reflex amplitude unlike in wild-type mice
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• on day 2, mice exhibit improved performance on a rotarod compared with wild-type mice
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• in an open field compared with wild-type mice
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• mice treated with a D3 receptor antagonist do not exhibit an increase in monosynaptic reflex strength unlike in similarly treated wild-type mice
• mice treated with D2 receptor agonists fail to exhibit a decrease in monosynaptic reflex strength compared with similarly treated wild-type mice
• mice treated with pergolide do not exhibit a difference in monosynaptic and longer-latency reflex amplitudes unlike in similarly treated wild-type mice
• mice treated with GR 103691 exhibit shorter monosynaptic than longer-latency reflex amplitude unlike in wild-type mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| restless legs syndrome | DOID:0050425 |
OMIM:PS102300 |
J:96803 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• during chronic ethanol treatment
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• mice treated with cocaine exhibit reduced hyperactivity and increased head bobbing compared with similarly treated wild-type mice
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• after a single injection of ethanol, mice exhibit reduced onset time to sleep and longer sleep time compared with similarly treated wild-type mice
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• 3 and 6 hours after discontinuation of ethanol treatment, mice exhibit increased levels of withdrawal scores compared with similarly treated wild-type mice
• however, withdrawal scores at 12 and 18 hours are normal
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• cocaine-treated mice exhibit increased head bobbing compared with similarly treated wild-type mice
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• 5 days after cocaine treatment, mice exhibit less induced locomotion compared with similarly treated wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit decreased morphine-induced conditioned place preference (CPP) compared with similarly treated wild-type mice
• BP 897-treated mice fail to exhibit a decrease in morphine-induced CPP compared with similarly treated wild-type mice
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• mice exhibit decreased morphine-induced conditioned place preference (CPP) compared with similarly treated wild-type mice
• BP 897-treated mice fail to exhibit a decrease in morphine-induced CPP compared with similarly treated wild-type mice
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• homozygotes exhibit increased exploratory behavior in the open field test
• in contrast, normal gait, coordination and primitive reflexes remain intact
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• homozygotes tend to show reduced grooming behavior with a delayed onset; however, these differences are not statistically significant relative to wild-type grooming behavior
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• in the open field test, homozygotes display hyperactivity, as shown by a 57% increase in locomotor activity (crossings) relative to wild-type mice
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• in the open field test, homozygotes display 93% more rearing episodes than wild-type mice
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• systolic blood pressure in losartan-treated mice remains depressed longer than similarly treated wild-type mice
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• after anesthesia with pentobarbital
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• after anesthesia with pentobarbital
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• after acute saline loading
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• in the kidneys
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• systolic blood pressure in losartan-treated mice remains depressed longer than similarly treated wild-type mice
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• after acute saline loading
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• after acute saline loading, urine flow is decreased compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit more time in the center of the open field and with the open arms of an elevated plus maze compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• heterozygotes exhibit increased exploratory behavior in the open field, with a degree of hyperactivity comparable to than of homozygotes during the last 11 min of a 15-min test
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• heterozygotes tend to show reduced grooming behavior with a delayed onset; however, these differences are not statistically significant relative to wild-type grooming behavior
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• during the first part of the test (increased early and decreased late) unlike wild-type mice
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• in the open field test, heterozygotes display hyperactivity, as shown by a 38% increase in locomotor activity (crossings) relative to wild-type mice
(J:32128)
• during the first part of the test
(J:96229)
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• in the open field test, heterozygotes display 77% more rearing episodes than wild-type mice
(J:32128)
• during the first part of the test
(J:96229)
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• after anesthesia with pentobarbital
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• after anesthesia with pentobarbital
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit moderately more time in the center of the open field and with the open arms of an elevated plus maze compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in a non-selective attention test, mice exhibit lower scanning times (measured by duration of individual rearing episodes) during the first part of the test compared with wild-type mice
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• mice exhibit a reduction in defecation score, as an emotional index, compared with wild-type mice
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• frequency and duration
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• mice exhibit a reduction in defecation score, as an emotional index, compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal numbers of entries into the open arms of an elevated plus maze compared with wild-type mice
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• in a Morris water maze
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• mice tend to float in the water instead of swimming compared with wild-type mice
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• in the water
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• compared with wild-type mice
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• mice exhibit lower swim speed compared with wild-type mice
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• in an open field compared with wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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