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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Drd3tm1Dac
targeted mutation 1, Domenico Accili
MGI:1857159
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Drd3tm1Dac/Drd3tm1Dac B6.129S4-Drd3tm1Dac MGI:4839990
hm2
Drd3tm1Dac/Drd3tm1Dac B6.129S4-Drd3tm1Dac/J MGI:4839954
hm3
Drd3tm1Dac/Drd3tm1Dac involves: 129S4/SvJae MGI:4839961
hm4
Drd3tm1Dac/Drd3tm1Dac involves: 129S4/SvJae * C57BL/6 MGI:3614420
hm5
Drd3tm1Dac/Drd3tm1Dac involves: 129S4/SvJae * C57BL/6J MGI:4839942
ht6
Drd3tm1Dac/Drd3+ involves: 129S4/SvJae * C57BL/6 MGI:3614421
ht7
Drd3tm1Dac/Drd3+ involves: 129S4/SvJae * C57BL/6J MGI:4839943
cx8
Drd2tm1Ebo/Drd2tm1Ebo
Drd3tm1Dac/Drd3tm1Dac
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 MGI:4839981
cx9
Drd1tm1Jcd/Drd1tm1Jcd
Drd3tm1Dac/Drd3tm1Dac
involves: 129S4/SvJae * C57BL/6 MGI:4839955


Genotype
MGI:4839990
hm1
Allelic
Composition
Drd3tm1Dac/Drd3tm1Dac
Genetic
Background
B6.129S4-Drd3tm1Dac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd3tm1Dac mutation (2 available); any Drd3 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit reduced acoustic startle response amplitude compared with wild-type mice




Genotype
MGI:4839954
hm2
Allelic
Composition
Drd3tm1Dac/Drd3tm1Dac
Genetic
Background
B6.129S4-Drd3tm1Dac/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd3tm1Dac mutation (2 available); any Drd3 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit increased entry into open arms in an elevated plus maze compared with wild-type mice
• mice exhibit more large-reflex amplitudes for both monosynaptic 'stretch' reflex (MSR) and longer-latency reflex responses compared with wild-type mice
• mice treated with 1 or 5 um dopamine exhibit led to an increase in MSR amplitude and reflex strength unlike in similarly treated wild-type mice
• mice treated with a D3 receptor antagonist do not exhibit an increase in monosynaptic reflex strength unlike in similarly treated wild-type mice
• mice treated with D2 receptor agonists fail to exhibit a decrease in monosynaptic reflex strength compared with similarly treated wild-type mice
• mice treated with pergolide do not exhibit a difference in monosynaptic and longer-latency reflex amplitudes unlike in similarly treated wild-type mice
• mice treated with GR 103691 exhibit shorter monosynaptic than longer-latency reflex amplitude unlike in wild-type mice
• on day 2, mice exhibit improved performance on a rotarod compared with wild-type mice
• in an open field compared with wild-type mice

homeostasis/metabolism
• mice treated with a D3 receptor antagonist do not exhibit an increase in monosynaptic reflex strength unlike in similarly treated wild-type mice
• mice treated with D2 receptor agonists fail to exhibit a decrease in monosynaptic reflex strength compared with similarly treated wild-type mice
• mice treated with pergolide do not exhibit a difference in monosynaptic and longer-latency reflex amplitudes unlike in similarly treated wild-type mice
• mice treated with GR 103691 exhibit shorter monosynaptic than longer-latency reflex amplitude unlike in wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
restless legs syndrome DOID:0050425 OMIM:PS102300
J:96803




Genotype
MGI:4839961
hm3
Allelic
Composition
Drd3tm1Dac/Drd3tm1Dac
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd3tm1Dac mutation (2 available); any Drd3 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• during chronic ethanol treatment
• mice treated with cocaine exhibit reduced hyperactivity and increased head bobbing compared with similarly treated wild-type mice
• after a single injection of ethanol, mice exhibit reduced onset time to sleep and longer sleep time compared with similarly treated wild-type mice
• however, withdrawal scores at 12 and 18 hours are normal
• 3 and 6 hours after discontinuation of ethanol treatment, mice exhibit increased levels of withdrawal scores compared with similarly treated wild-type mice
• cocaine-treated mice exhibit increased head bobbing compared with similarly treated wild-type mice
• 5 days after cocaine treatment, mice exhibit less induced locomotion compared with similarly treated wild-type mice




Genotype
MGI:3614420
hm4
Allelic
Composition
Drd3tm1Dac/Drd3tm1Dac
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd3tm1Dac mutation (2 available); any Drd3 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit decreased morphine-induced conditioned place preference (CPP) compared with similarly treated wild-type mice
• BP 897-treated mice fail to exhibit a decrease in morphine-induced CPP compared with similarly treated wild-type mice
• mice exhibit decreased morphine-induced conditioned place preference (CPP) compared with similarly treated wild-type mice
• BP 897-treated mice fail to exhibit a decrease in morphine-induced CPP compared with similarly treated wild-type mice
• homozygotes exhibit increased exploratory behavior in the open field test
• in contrast, normal gait, coordination and primitive reflexes remain intact
• homozygotes tend to show reduced grooming behavior with a delayed onset; however, these differences are not statistically significant relative to wild-type grooming behavior
• in the open field test, homozygotes display hyperactivity, as shown by a 57% increase in locomotor activity (crossings) relative to wild-type mice
• in the open field test, homozygotes display 93% more rearing episodes than wild-type mice

cardiovascular system
• systolic blood pressure in losartan-treated mice remains depressed longer than similarly treated wild-type mice
• after anesthesia with pentobarbital
• after anesthesia with pentobarbital

homeostasis/metabolism
• after acute saline loading
• in the kidneys
• systolic blood pressure in losartan-treated mice remains depressed longer than similarly treated wild-type mice

renal/urinary system
• after acute saline loading
• after acute saline loading, urine flow is decreased compared to in wild-type mice




Genotype
MGI:4839942
hm5
Allelic
Composition
Drd3tm1Dac/Drd3tm1Dac
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd3tm1Dac mutation (2 available); any Drd3 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit more time in the center of the open field and with the open arms of an elevated plus maze compared with wild-type mice




Genotype
MGI:3614421
ht6
Allelic
Composition
Drd3tm1Dac/Drd3+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd3tm1Dac mutation (2 available); any Drd3 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• heterozygotes exhibit increased exploratory behavior in the open field, with a degree of hyperactivity comparable to than of homozygotes during the last 11 min of a 15-min test
• heterozygotes tend to show reduced grooming behavior with a delayed onset; however, these differences are not statistically significant relative to wild-type grooming behavior
• during the first part of the test (increased early and decreased late) unlike wild-type mice
• in the open field test, heterozygotes display hyperactivity, as shown by a 38% increase in locomotor activity (crossings) relative to wild-type mice (J:32128)
• during the first part of the test (J:96229)
• in the open field test, heterozygotes display 77% more rearing episodes than wild-type mice (J:32128)
• during the first part of the test (J:96229)

cardiovascular system
• after anesthesia with pentobarbital
• after anesthesia with pentobarbital

homeostasis/metabolism




Genotype
MGI:4839943
ht7
Allelic
Composition
Drd3tm1Dac/Drd3+
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd3tm1Dac mutation (2 available); any Drd3 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit moderately more time in the center of the open field and with the open arms of an elevated plus maze compared with wild-type mice




Genotype
MGI:4839981
cx8
Allelic
Composition
Drd2tm1Ebo/Drd2tm1Ebo
Drd3tm1Dac/Drd3tm1Dac
Genetic
Background
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd2tm1Ebo mutation (0 available); any Drd2 mutation (63 available)
Drd3tm1Dac mutation (2 available); any Drd3 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in a non-selective attention test, mice exhibit lower scanning times (measured by duration of individual rearing episodes) during the first part of the test compared with wild-type mice
• mice exhibit a reduction in defecation score, as an emotional index, compared with wild-type mice
• frequency and duration

digestive/alimentary system
• mice exhibit a reduction in defecation score, as an emotional index, compared with wild-type mice




Genotype
MGI:4839955
cx9
Allelic
Composition
Drd1tm1Jcd/Drd1tm1Jcd
Drd3tm1Dac/Drd3tm1Dac
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd1tm1Jcd mutation (2 available); any Drd1 mutation (62 available)
Drd3tm1Dac mutation (2 available); any Drd3 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal numbers of entries into the open arms of an elevated plus maze compared with wild-type mice
• in a Morris water maze
• mice tend to float in the water instead of swimming compared with wild-type mice
• in the water
• compared with wild-type mice
• mice exhibit lower swim speed compared with wild-type mice
• in an open field compared with wild-type mice

growth/size/body





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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory