About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
sy
shaker with syndactylism
MGI:1856182
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
sy/sy B6C3Fe-a/a MGI:2451235
hm2
sy/sy Not Specified MGI:2174750
cx3
Slc12a2sy-ns/sy involves: C57BL/6 * MK/ReJ MGI:3698318


Genotype
MGI:2451235
hm1
Allelic
Composition
sy/sy
Genetic
Background
B6C3Fe-a/a
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
sy mutation (1 available); any sy mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• variable penetrance, usually of digits 2 and 3 or 3 and 4, more rarely 2, 3 and 4; fusion of 2, 3 and 4 is more frequently seen on the hind paw than the fore paws

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Arthrogryposis, Distal, Type 9; DA9 121050 J:68881




Genotype
MGI:2174750
hm2
Allelic
Composition
sy/sy
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
sy mutation (1 available); any sy mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• within 1 month of birth

behavior/neurological

hearing/vestibular/ear
• thin semicircular canals
• development of excessive mesenchymal tissue followed by collapse of endolymphatic space and degeneration of membraneous labyrinth

limbs/digits/tail
• variable penetrance
• usually of digits 2 and 3 or 3 and 4

skeleton
• synostosis of phalanges
• variable penetrance




Genotype
MGI:3698318
cx3
Allelic
Composition
Slc12a2sy-ns/sy
Genetic
Background
involves: C57BL/6 * MK/ReJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc12a2sy-ns mutation (1 available); any Slc12a2 mutation (21 available)
sy mutation (1 available); any sy mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological

hearing/vestibular/ear
• no discernible auditory brainstem responses (ABR) to maximum output stimuli at 99 dB
• profoundly deaf at 2-3 month of age





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory