All Phenotypes Myo5a<d-l> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Myo5a^d-l
dilute lethal
MGI:1856005

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myo5a^d-l/Myo5a^d-l	involves: C57BL	MGI:3813263
ht2	Myo5a^d-90H/Myo5a^d-l	involves: 101/H * C3H/HeH * C57BL/Gr	MGI:5301940
ht3	Myo5a^d-93H/Myo5a^d-l	involves: 101/H * C3H/HeH * C57BL/Gr	MGI:5301941
cx4	Myo5a^d-l/d-100H	involves: C3H/HeH * C57BL/Gr	MGI:5311912

Allelic Composition	Myo5a^d-l/Myo5a^d-l
Genetic Background	involves: C57BL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5a^d-l mutation (2 available); any Myo5a mutation (265 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired righting response ( J:12978 )

opisthotonus ( J:12978 )

• arching is very extreme

impaired balance ( J:12978 )

• hardly able to walk by 12 days of age

• moves on its side and in circles trying to stand

impaired limb coordination ( J:12978 )

clonic seizures ( J:12978 )

• 9 day old mutants show slight convulsive limb movements

• by 12 days of age convulsions are marked with fore-limbs thrashing

• by 15 days of age convulsions are triggered when mouse is disturbed, overbalances and falls and occur while mouse regains upright posture

muscle

opisthotonus ( J:12978 )

• arching is very extreme

nervous system

clonic seizures ( J:12978 )

• 9 day old mutants show slight convulsive limb movements

• by 12 days of age convulsions are marked with fore-limbs thrashing

• by 15 days of age convulsions are triggered when mouse is disturbed, overbalances and falls and occur while mouse regains upright posture

pigmentation

diluted coat color ( J:12978 )

integument

diluted coat color ( J:12978 )

Allelic Composition	Myo5a^d-90H/Myo5a^d-l
Genetic Background	involves: 101/H * C3H/HeH * C57BL/Gr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5a^d-90H mutation (0 available); any Myo5a mutation (265 available)
Myo5a^d-l mutation (2 available); any Myo5a mutation (265 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

opisthotonus ( J:179353 )

muscle

opisthotonus ( J:179353 )

Allelic Composition	Myo5a^d-93H/Myo5a^d-l
Genetic Background	involves: 101/H * C3H/HeH * C57BL/Gr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5a^d-93H mutation (0 available); any Myo5a mutation (265 available)
Myo5a^d-l mutation (2 available); any Myo5a mutation (265 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

opisthotonus ( J:179353 )

muscle

opisthotonus ( J:179353 )

Allelic Composition	Myo5a^d-l/d-100H
Genetic Background	involves: C3H/HeH * C57BL/Gr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
d-100H mutation (0 available); any d-100H mutation (0 available)
Myo5a^d-l mutation (2 available); any Myo5a mutation (265 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

abnormal survival ( J:181531 )

• lethal

behavior/neurological

opisthotonus ( J:181531 )

muscle

opisthotonus ( J:181531 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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