All Phenotypes A<vy> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

A^vy
agouti viable yellow
MGI:1855930

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	A^vy/A^vy	involves: C3H/HeJ	MGI:2675354
ht2	A^vy/A^w	129S1.C3-A^vy/A^w Chr 19^MOLF/Ei	MGI:3838979
ht3	A^vy/a	involves: C3H/HeJ * C57BL/6	MGI:3772367
ht4	A^vy/a	involves: C57BL/6J	MGI:3778284
cx5	A^vy/a Axin1^Fu/Axin1⁺	involves: 129P4/RrRk * C67BL/6J	MGI:3778273
cx6	A^vy/A Smarca5^MommeD4/Smarca5⁺	involves: C57BL/6J * FVB/NJ	MGI:3607160
cx7	A^vy/A Dnmt1^MommeD2/Dnmt1⁺	involves: C57BL/6J * FVB/NJ	MGI:3607157
cx8	A^vy/A Smchd1^MommeD1/Smchd1⁺	involves: C57BL/6J * FVB/NJ	MGI:3607153
ot9	A^vy/?	129S1.C3-A^vy	MGI:3838981

Allelic Composition	A^vy/A^vy
Genetic Background	involves: C3H/HeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A^vy mutation (4 available); any a mutation (463 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:13080 )

integument

abnormal coat/hair pigmentation ( J:13080 )

Allelic Composition	A^vy/A^w
Genetic Background	129S1.C3-A^vy/A^w Chr 19^MOLF/Ei

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A^vy mutation (4 available); any a mutation (463 available)
A^w mutation (14 available); any a mutation (463 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:146879 )

N	• mice exhibit the same incidence of testicular germ cell tumors as in 129S1/SvImJ-Chr 19/Na mice

Allelic Composition	A^vy/a
Genetic Background	involves: C3H/HeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^vy mutation (4 available); any a mutation (463 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Spectrum of coat colors in A^vy/a mice

growth/size/body

obese ( J:117156 )

pigmentation

abnormal coat/hair pigmentation ( J:117156 )

• variable coat color ranging from yellow, mosaic yellow/agouti, or pseudoagouti

variegated coat color ( J:117156 )

neoplasm

increased tumor incidence ( J:117156 )

integument

abnormal coat/hair pigmentation ( J:117156 )

• variable coat color ranging from yellow, mosaic yellow/agouti, or pseudoagouti

variegated coat color ( J:117156 )

cellular

abnormal epigenetic regulation of gene expression ( J:117156 )

• sires mated with a/a dams, but not dams mated with a/a sires, that were supplemented with methyl donors ((folate, choline, betaine, vitamin B12, zinc, and methionine) during pregnancy show a significant shift in the spectrum of color phenotypes toward pseudoagouti, indicating that in utero methyl donor supplementation affects the somatic epigenetic state of the A^vy allele only when the allele is derived from the male

• F1 pseudoagouti females that had been exposed to methyl donors in utero from E8.5 to E15.5 and mated to a/a males without further methyl donor supplementation, produce offspring (F2) showing a sift toward pseudoagouti coloration, indicating that diet/environment has an enduring influence on succeeding generations, independent of later changes in diet

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:13142 , J:117156

Allelic Composition	A^vy/a
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^vy mutation (4 available); any a mutation (463 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

variegated coat color ( J:82396 )

integument

variegated coat color ( J:82396 )

cellular

abnormal epigenetic regulation of gene expression ( J:82396 )

• this allele is heavily methylated in the sperm of agouti colored males but hypomethylated in the sperm of yellow males

Allelic Composition	A^vy/a Axin1^Fu/Axin1⁺
Genetic Background	involves: 129P4/RrRk * C67BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
A^vy mutation (4 available); any a mutation (463 available)
Axin1^Fu mutation (1 available); any Axin1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

genetic imprinting ( J:82396 )

• penetrance of fused and viable yellow are independent of each other with double heterozygotes displaying all combinations of coat color and tail phenotypes due to independent variations in penetrance of each

Allelic Composition	A^vy/A Smarca5^MommeD4/Smarca5⁺
Genetic Background	involves: C57BL/6J * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (19 available); any a mutation (463 available)
A^vy mutation (4 available); any a mutation (463 available)
Smarca5^MommeD4 mutation (1 available); any Smarca5 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

mottled coat ( J:99816 )

• when a MommeD4 sire is mated to a yellow dam offspring with the MommeD4 allele are more likely to be mottled

integument

mottled coat ( J:99816 )

• when a MommeD4 sire is mated to a yellow dam offspring with the MommeD4 allele are more likely to be mottled

Allelic Composition	A^vy/A Dnmt1^MommeD2/Dnmt1⁺
Genetic Background	involves: C57BL/6J * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (19 available); any a mutation (463 available)
A^vy mutation (4 available); any a mutation (463 available)
Dnmt1^MommeD2 mutation (0 available); any Dnmt1 mutation (108 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

yellow coat color ( J:99816 )

• more female pups with yellow coat color are produced when a MommeD1 dam is crossed with a psuedoagouti sire but not when the reciprocal cross is made

integument

yellow coat color ( J:99816 )

• more female pups with yellow coat color are produced when a MommeD1 dam is crossed with a psuedoagouti sire but not when the reciprocal cross is made

Allelic Composition	A^vy/A Smchd1^MommeD1/Smchd1⁺
Genetic Background	involves: C57BL/6J * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (19 available); any a mutation (463 available)
A^vy mutation (4 available); any a mutation (463 available)
Smchd1^MommeD1 mutation (0 available); any Smchd1 mutation (143 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

yellow coat color ( J:99816 )

• more female pups with yellow coat color are produced when a MommeD1 sire is crossed with a psuedoagouti dam but not when the reciprocal cross is made

integument

yellow coat color ( J:99816 )

• more female pups with yellow coat color are produced when a MommeD1 sire is crossed with a psuedoagouti dam but not when the reciprocal cross is made

Allelic Composition	A^vy/?
Genetic Background	129S1.C3-A^vy

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A^vy mutation (4 available); any a mutation (463 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:146879 )

N	• mice exhibit the same incidence of testicular germ cell tumors as in 129/Sv mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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