Igs2^{tm2(Rr555999-lacZ)Kco}
Targeted Allele Detail

Summary

• Symbol: Igs2^{tm2(Rr555999-lacZ)Kco}
• Name: intergenic site 2; targeted mutation 2, Kerby C Oberg
• MGI ID: MGI:8245534
• Gene: Igs2 Location: Chr11:3195460-3195497 bp Genetic Position: Chr11, Syntenic
• Alliance: Igs2^{tm2(Rr555999-lacZ)Kco} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:362224
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details:

  The transgene construct contains the following elements: Lhx2 embryonic limb enhancer Rr555999 (Lhx2-associated sub-AER regulatory module, LASARM) from a Dennd1a intron, minimal Shh promoter, betagalactosidase reporter gene cDNA, and SV40 poly(A) signal sequences. The enhancer drives expression of the reporter in the distal limbs of E11.5 embryos. (J:362224)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igs2 Mutation: 54 strains or lines available

References

• Original: J:362224 Britton JC, et al., Evidence for Fgf and Wnt regulation of Lhx2 during limb development via two limb-specific Lhx2-associated cis-regulatory modules. Front Cell Dev Biol. 2025;13:1552716
• All: 1 reference(s)