Gt(ROSA)26Sor^{tm1(CAG-Satb1,-EGFP)Bey}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Satb1,-EGFP)Bey}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Marc Beyer
• MGI ID: MGI:8224008
• Synonyms: R26-STOP-Satb1
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Satb1,-EGFP)Bey} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:370027
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-Satb1,-EGFP)Bey} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Satb1 (MGI:105084)

• Gt(ROSA)26Sor^{tm1(CAG-Satb1,-EGFP)Bey} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  chicken	CAG

• Mutation details:

  This allele allows conditional Satb1 overexpression from the Gt(ROSA)26Sor gene. The inserted construct contains a loxP-flanked neomycin/stop cassette, followed by the mouse Satb1 cDNA sequence, an internal ribosome entry site (IRES), and eGFP gene, allowing overexpression to be tracked via eGFP after Cre-mediated recombination. (J:370027)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1213 strains or lines available

References

• Original: J:370027 Kohne M, et al., Satb1 directs the differentiation of T(H)17 cells through suppression of IL-2 expression. Cell Rep. 2025 Jun 17;44(7):115866
• All: 1 reference(s)