Tti2^{tm1c(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Tti2^{tm1c(KOMP)Wtsi}
• Name: TELO2 interacting protein 2; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:8164050
• Gene: Tti2 Location: Chr8:31640344-31654731 bp, + strand Genetic Position: Chr8, 18.03 cM
• Alliance: Tti2^{tm1c(KOMP)Wtsi} page
• IMPC: Tti2 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:342743
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 31643038 of Chromosome 8 upstream of exon 2 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 2 at position 31643914. Flp-mediated recombination removed the LacZ and neo cassettes, leaving loxP sites flanking exon 2. (J:342743)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tti2 Mutation: 21 strains or lines available

References

• Original: J:342743 Meziane H, et al., Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models. Biomedicines. 2022 Dec 6;10(12)
• All: 1 reference(s)