Slc4a3^em1Brsk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc4a3^em1Brsk
• Name: solute carrier family 4 (anion exchanger), member 3; endonuclease-mediated mutation 1, Botond Roska
• MGI ID: MGI:7789055
• Synonyms: Slc4a3^tm1
• Gene: Slc4a3 Location: Chr1:75522688-75536075 bp, + strand Genetic Position: Chr1, 39.16 cM, cytoband C3
• Alliance: Slc4a3^em1Brsk page

Mutation origin

• Strain of Origin: (C57BL/6J x BALB/c)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using CRISPR/Cas9 engineering, exon 13 of Slc4a3 (NM_009208) was targeted with two antiparallel gRNAs to target the genomic sequence resulting in 25 bp deletion ain exon 13 predicted to cause a premature stop codon before the first transmembrane regions. (J:358138)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc4a3 Mutation: 42 strains or lines available

References

• Original: J:358138 Morikawa R, et al., The sodium-bicarbonate cotransporter Slc4a5 mediates feedback at the first synapse of vision. Neuron. 2024 Sep 18
• All: 1 reference(s)