Gpsm2^{tm1d(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Gpsm2^{tm1d(EUCOMM)Wtsi}
• Name: G-protein signalling modulator 2 (AGS3-like, C. elegans); targeted mutation 1d, Wellcome Trust Sanger Institute
• MGI ID: MGI:7788462
• Synonyms: Gpsm2 KO
• Gene: Gpsm2 Location: Chr3:108585954-108629625 bp, - strand Genetic Position: Chr3, 47.53 cM, cytoband F3
• Alliance: Gpsm2^{tm1d(EUCOMM)Wtsi} page
• IMPC: Gpsm2 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:359565
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The L1L2_gt0 cassette was inserted at position 108608828 of Chromosome 3 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 108609458. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by flp and cre recombinase expression in mice carrying this allele to remove the lacZ sequence, neo selection cassette and the loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:359565)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpsm2 Mutation: 26 strains or lines available

References

• Original: J:359565 Housset M, et al., Identification of a non-canonical planar cell polarity pathway triggered by light in the developing mouse retina. Dev Cell. 2024 Nov 15
• All: 1 reference(s)