Gpsm2^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Gpsm2^{tm1c(EUCOMM)Wtsi}
• Name: G-protein signalling modulator 2 (AGS3-like, C. elegans); targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:7788461
• Synonyms: Gpsm2^fl
• Gene: Gpsm2 Location: Chr3:108585954-108629625 bp, - strand Genetic Position: Chr3, 47.53 cM, cytoband F3
• Alliance: Gpsm2^{tm1c(EUCOMM)Wtsi} page
• IMPC: Gpsm2 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:359565
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_gt0 cassette was inserted at position 108608828 of Chromosome 3 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 108609458. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:359565)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpsm2 Mutation: 26 strains or lines available

References

• Original: J:359565 Housset M, et al., Identification of a non-canonical planar cell polarity pathway triggered by light in the developing mouse retina. Dev Cell. 2024 Nov 15
• All: 2 reference(s)