Nrxn1^tm1.2Schei
Targeted Allele Detail

Summary

• Symbol: Nrxn1^tm1.2Schei
• Name: neurexin I; targeted mutation 1.2, Peter Scheiffele
• MGI ID: MGI:7785238
• Synonyms: Nrxn1^deltaex21
• Gene: Nrxn1 Location: Chr17:90341059-91400499 bp, - strand Genetic Position: Chr17, 59.73 cM
• Alliance: Nrxn1^tm1.2Schei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232552
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129/Sv x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP-Frt-PGKneo-Frt cassette was inserted 982 bp 5'-upstream of exon 21 and a loxP site placed 557 bp 3'downstream of the same exon. The selection cassette was removed via FLP-mediated recombination in the germline. Subsequent Cre-mediated recombination in the germline removed exon 21. (J:232552)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrxn1 Mutation: 102 strains or lines available

References

• Original: J:232552 Traunmuller L, et al., Control of neuronal synapse specification by a highly dedicated alternative splicing program. Science. 2016 May 20;352(6288):982-6
• All: 2 reference(s)