Ccdc57^{tm1b(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Ccdc57^{tm1b(EUCOMM)Wtsi}
• Name: coiled-coil domain containing 57; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:7785129
• Synonyms: Ccdc57^-
• Gene: Ccdc57 Location: Chr11:120717355-120823698 bp, - strand Genetic Position: Chr11, 84.59 cM, cytoband E2
• Alliance: Ccdc57^{tm1b(EUCOMM)Wtsi} page
• IMPC: Ccdc57 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:358923
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The L1L2_gt2 cassette was inserted at position 120810024 of Chromosome 11 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 120811027. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by cre recombinase expression in mice carrying the tm1a allele to remove the neo selection cassette and loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:358923)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccdc57 Mutation: 58 strains or lines available

References

• Original: J:358923 Pan X, et al., Directional ciliary beats across epithelia require Ccdc57-mediated coupling between axonemal orientation and basal body polarity. Nat Commun. 2024 Nov 26;15(1):10249
• All: 1 reference(s)