Tg(AR*121Q)3Als
Transgene Detail

Summary

• Symbol: Tg(AR*121Q)3Als
• Name: transgene insertion 3, Albert La Spada
• MGI ID: MGI:7767964
• Synonyms: BAC fxAR121
• Transgene: Tg(AR*121Q)3Als Location: unknown
• Alliance: Tg(AR*121Q)3Als page

Transgene origin

• Strain of Origin: (C57BL/6J x C3H/HeJ)F1

Transgene description

• Transgene Type: Transgenic (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(AR*121Q)3Als expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  AR (367)

  Ar	(MGI:88064)

• Mutation details: The transgene was designed by fusing two bacterial artificial chromosomes (BACs) to create an AR BAC construct that includes all eight exons (~180 kbp) of the human androgen receptor gene (AR), ~50 kbp of flanking sequence transcriptionally-upstream of the first AR exon and ~23 kbp of flanking sequence transcriptionally-downstream of the last AR exon. Next, AR exon 1 (which includes the translational start site) was flanked with loxP sites, and a 121 glutamine tract (stabilized with CAA interruptions) was introduced into AR exon 1. No other complete loci exist in the 5' or 3' flanking BAC regions. The founder line 3 identified with 121 polyQ repeats was established. (J:101977, J:214015)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:214015 Cortes CJ, et al., Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophy. Neuron. 2014 Apr 16;82(2):295-307
• All: 3 reference(s)