Igs2^{em1(Rr428-lacZ,-icre)Yzhou}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Igs2^{em1(Rr428-lacZ,-icre)Yzhou}
• Name: intergenic site 2; endonuclease-mediated mutation 1, Yan Zhou
• MGI ID: MGI:7766963
• Synonyms: H11^i.enh
• Gene: Igs2 Location: Chr11:3195460-3195497 bp Genetic Position: Chr11, Syntenic
• Alliance: Igs2^{em1(Rr428-lacZ,-icre)Yzhou} page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Reporter)
• Mutation: Insertion
• Mutation details: The following elements were inserted into the locus using Cas9: Shh promoter, 2,153 bp core region (CR) of Ctnnb1 enhancer Rr428, a beta-galactosidase reporter gene cassette and the icre recombinase gene. (J:355476)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igs2 Mutation: 72 strains or lines available

References

• Original: J:355476 Hua X, et al., A Ctnnb1 enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epithelia. Elife. 2024 Sep 25;13
• All: 1 reference(s)