Ccnd1^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Ccnd1^tm1.1Ics
• Name: cyclin D1; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:7738813
• Synonyms: 4-5^flox
• Gene: Ccnd1 Location: Chr7:144483668-144493568 bp, - strand Genetic Position: Chr7, 88.92 cM
• Alliance: Ccnd1^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:355395
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 3 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 4. The neo cassette was removed through subsequent Flp-mediated recombination, leaving a conditional-ready allele with exon 4 floxed. (J:355395)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccnd1 Mutation: 23 strains or lines available

References

• Original: J:355395 Chaves-Ferreira M, et al., The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells. Biol Direct. 2016 Apr 29;11:21
• All: 1 reference(s)