Gt(ROSA)26Sor^{tm3(CIC/DUX4)Dgk}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm3(CIC/DUX4)Dgk}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, David Kirsch
• MGI ID: MGI:7738808
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm3(CIC/DUX4)Dgk} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:347765
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Epitope tag, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm3(CIC/DUX4)Dgk} expresses 2 genes
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CIC (23152)

  Cic	(MGI:1918972)

  human

  DUX4 (100288687)

  Duxf3	(MGI:1921649)
  Duxf4	(MGI:3645498)

• Mutation details: A loxP-stop-loxP cassette with additional stop sequences (TOPO) and N-terminal 3x HA-tagged human CIC::DUX4 fusion gene were inserted via homologous recombination. (J:347765)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1096 strains or lines available

References

• Original: J:347765 Hendrickson PG, et al., Spontaneous expression of the CIC::DUX4 fusion oncoprotein from a conditional allele potently drives sarcoma formation in genetically engineered mice. Oncogene. 2024 Apr;43(16):1223-1230
• All: 1 reference(s)