Rr29^em1Ezk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr29^em1Ezk
• Name: regulatory region 29; endonuclease-mediated mutation 1, Evgeny Z Kvon
• MGI ID: MGI:7711246
• Synonyms: ZRS^lacZ
• Gene: Rr29 Location: Chr5:29519495-29520860 bp, + strand
• Alliance: Rr29^em1Ezk page

Mutation origin

• Strain of Origin: FVB

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.3 kb region containing the MFCS1 or ZRS enhancer of Shh (located in an intron of Lmbr1) was replaced with part of the lacZ reporter gene sequence using an sgRNA and a DNA template with CRISPR/Cas9 technology. (J:347410)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr29 Mutation: 2 strains or lines available

References

• Original: J:347410 Chen Z, et al., Increased enhancer-promoter interactions during developmental enhancer activation in mammals. Nat Genet. 2024 Apr;56(4):675-685
• All: 2 reference(s)