Rr250409^em1Kejz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr250409^em1Kejz
• Name: regulatory region 250409; endonuclease-mediated mutation 1, Keji Zhao
• MGI ID: MGI:7709976
• Synonyms: HSS^delta
• Gene: Rr250409 Location: Chr11:53517402-53519171 bp Genetic Position: Chr11, Syntenic
• Alliance: Rr250409^em1Kejz page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intergenic deletion
• Mutation details: The CTCF-binding site in a DNase I hypersensitive site (Il4, Il5 and Il13 enhancer) was targeted with sgRNAs using CRISPR/Cas9 technology, resulting in a 172 bp deletion (GRCm39:chr11:53518901-53518972). (J:349483)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr250409 Mutation: 0 strains or lines available

References

• Original: J:349483 Liu S, et al., Regulation of T helper cell differentiation by the interplay between histone modification and chromatin interaction. Immunity. 2024 Apr 5
• All: 1 reference(s)