Del(19Rbm4b-Rbm4)1Wtarn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Del(19Rbm4b-Rbm4)1Wtarn
• Name: deletion, Chr 10, Yann Herault 1; deletion, Chr 19, Woan-Yuh Tarn 1
• MGI ID: MGI:7666674
• Synonyms: Rbm4dKO
• Gene: Del(19Rbm4b-Rbm4)1Wtarn Location: unknown Genetic Position: Chr19, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:340400
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intergenic deletion
• Del(19Rbm4b-Rbm4)1Wtarn involves 8 genes/genome features (Gm21992, Rbm4b, Rr360782 ...) View all
• Mutation details: Mice carrying Rbm4^tm1Wtarn and Rbm4b^em1Wtarn were crossed with an Tg(EIIa-cre)C5379Lmgd transgenic mouse line. Cre expression results in the excision of approximately 30 kb floxed region including 18.1kb of the intergenic region, Rbm4a (exons 2-4) and Rbm4b (exons 2-4) loci (containing predicted genes [Gm19103, Gm21992], regulatory regions [Rr358651, Rr360782, Rr360784] and the transcription start site region Tssr157511. This double knockout completely abolished Rbm4 and Rbm4b expression at both the mRNA and protein levels. (J:340400)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(19Rbm4b-Rbm4)1Wtarn Mutation: 1 strain or line available

References

• Original: J:340400 Tsai YY, et al., Activation of TrkB signaling mitigates cerebellar anomalies caused by Rbm4-Bdnf deficiency. Commun Biol. 2023 Sep 5;6(1):910
• All: 1 reference(s)