Adipoq^tm2.1Pesch
Targeted Allele Detail

Summary

• Symbol: Adipoq^tm2.1Pesch
• Name: adiponectin, C1Q and collagen domain containing; targeted mutation 2.1, Philipp E Scherer
• MGI ID: MGI:7664415
• Synonyms: APN^fl
• Gene: Adipoq Location: Chr16:22965286-22976718 bp, + strand Genetic Position: Chr16, 13.96 cM, cytoband B3-B4
• Alliance: Adipoq^tm2.1Pesch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261576
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites and an frt-flanked neomycin selection cassette were inserted to flanked exons 1 and 2. The frt-flanked neomycin selection cassette was removed via FLP-mediated recombination. (J:261576)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adipoq Mutation: 41 strains or lines available

References

• Original: J:261576 Xia JY, et al., Acute loss of adipose tissue-derived adiponectin triggers immediate metabolic deterioration in mice. Diabetologia. 2018 Apr;61(4):932-941
• All: 2 reference(s)