Ctla4^{em1(CTLA4)Cya}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ctla4^{em1(CTLA4)Cya}
• Name: cytotoxic T-lymphocyte-associated protein 4; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7657237
• Synonyms: Ctla4^{em1(hCTLA4)Cya}
• Gene: Ctla4 Location: Chr1:60948184-60954991 bp, + strand Genetic Position: Chr1, 30.58 cM, cytoband C
• Alliance: Ctla4^{em1(CTLA4)Cya} page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Ctla4^{em1(CTLA4)Cya} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CTLA4 (1493)

  Ctla4

  (MGI:88556)

• Mutation details: The mouse Ctla4 gene was edited using gene editing technology to replace the sequence encoding the extracellular domain of mouse CTLA4 protein (aa.36~161) with the sequence from the human CTLA4 gene encoding the human CTLA4 protein extracellular domain (aa.36~161) while retaining the mouse signal peptide. (J:326541)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctla4 Mutation: 49 strains or lines available

References

• Original: J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022
• All: 1 reference(s)