Gria2^tm1.1Bviss
Targeted Allele Detail

Summary

• Symbol: Gria2^tm1.1Bviss
• Name: glutamate receptor, ionotropic, AMPA2 (alpha 2); targeted mutation 1.1, Bryce Vissel
• MGI ID: MGI:7643535
• Synonyms: Gria2^G, Gria2^tm1BViss
• Gene: Gria2 Location: Chr3:80588757-80710142 bp, - strand Genetic Position: Chr3, 35.5 cM
• Alliance: Gria2^tm1.1Bviss page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:348213
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details: Glutamine codon 607 (CAG) in exon 11 was changed to arginine (CGG) (p.Q607R) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 11. The neo cassette was removed through subsequent Cre-mediated recombination. The mutation mimics the RNA editing at that codon from CAG to CIG, which is translated as a CGG codon, in the brain. (J:348213)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gria2 Mutation: 78 strains or lines available

References

• Original: J:348213 Wright AL, et al., The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer's disease. Mol Neurodegener. 2023 Sep 28;18(1):65
• All: 1 reference(s)