Prkca^em1New
Endonuclease-mediated Allele Detail

Summary

• Symbol: Prkca^em1New
• Name: protein kinase C, alpha; endonuclease-mediated mutation 1, Alexandra C Newton
• MGI ID: MGI:7642206
• Synonyms: PKCalha-M489V, PrkcaM489V
• Gene: Prkca Location: Chr11:107824213-108234754 bp, - strand Genetic Position: Chr11, 70.8 cM
• Alliance: Prkca^em1New page

Mutation origin

• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/cas9 mediated recombination inserted an A to G substitution creating a Met to Val mutation at position 489. The amino acid substitution increases agonist evoked signaling output by the protein. (J:348558, J:348557)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkca Mutation: 44 strains or lines available

References

• Original: J:348558 Callender JA, et al., Protein kinase Calpha gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation. Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):E5497-E5505
• All: 2 reference(s)