Ildr2^em5099Tac
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ildr2^em5099Tac
• Name: immunoglobulin-like domain containing receptor 2; endonuclease-mediated mutation 5099, Taconic
• MGI ID: MGI:7639946
• Gene: Ildr2 Location: Chr1:166081708-166144392 bp, + strand Genetic Position: Chr1, 73.61 cM
• Alliance: Ildr2^em5099Tac page

Mutation origin

• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology deleted a 17.8 kb genomic region containing exons 1 and 2 (including the putative promoter region). The position of the cutting sites was 1.7 kb upstream of exon 1 and 0.6 kb downstream of exon 2. (J:347379)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ildr2 Mutation: 28 strains or lines available

References

• Original: J:347379 Huetter J, et al., Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2). Cancer Immunol Res. 2020 Jul;8(7):895-911
• All: 1 reference(s)