Tg(CAG-COX8A/Nox4)618Mrng
Transgene Detail

Summary

• Symbol: Tg(CAG-COX8A/Nox4)618Mrng
• Name: transgene insertion 618, Marschall S Runge
• MGI ID: MGI:7639788
• Transgene: Tg(CAG-COX8A/Nox4)618Mrng Location: unknown
• Alliance: Tg(CAG-COX8A/Nox4)618Mrng page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-COX8A/Nox4)618Mrng expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  COX8A (1351)

  Cox8a

  (MGI:105959)

  human

  NOX4 (50507)

  Nox4	(MGI:1354184)

• Tg(CAG-COX8A/Nox4)618Mrng expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  chicken	CAG

• Mutation details: The transgene was designed with (from 5' to 3') a CMV-IE enhancer/chicken beta-actin/rabbit beta-globin hybrid promoter (CAG), a linker peptide, and a fusion protein composed of a mitochondrial targeting pre-sequence (derived from human cytochrome c oxidase subunit VIII [COX8A]) fused to the N-terminal of the murine NADPH oxidase 4 (Nox4) gene. This is a high expression line 618. (J:290779)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:290779 Canugovi C, et al., Increased mitochondrial NADPH oxidase 4 (NOX4) expression in aging is a causative factor in aortic stiffening. Redox Biol. 2019 Sep;26:101288
• All: 2 reference(s)