Cybb^em1Tcf
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cybb^em1Tcf
• Name: cytochrome b-245, beta polypeptide; endonuclease-mediated mutation 1, Ralf Kuehn
• MGI ID: MGI:7616219
• Synonyms: CybbC517del
• Gene: Cybb Location: ChrX:9301493-9354005 bp, - strand Genetic Position: ChrX, 4.3 cM
• Alliance: Cybb^em1Tcf page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Single point mutation
• Mutation details: Using CRISPR/Cas9 endonuclease-genome editing, a single nucleotide deletion (C517) in exon 6 of the cytochrome b-245, beta polypeptide(Cybb) locus was introduced, resulting in a frameshift and loss of function. (J:348671)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cybb Mutation: 48 strains or lines available

References

• Original: J:348671 Sevim-wunderlich S, et al., A Mouse Model of X-Linked Chronic Granulomatous Disease for the Development of CRISPR/Cas9 Gene Therapy. Genes. 2024
• All: 1 reference(s)