Disp1^em2Ogd
Endonuclease-mediated Allele Detail

Summary

• Symbol: Disp1^em2Ogd
• Name: dispatched RND transporter family member 1; endonuclease-mediated mutation 2, Stacey K. Ogden
• MGI ID: MGI:7580473
• Synonyms: Disp1^CS
• Gene: Disp1 Location: Chr1:182867830-183003086 bp, - strand Genetic Position: Chr1, Syntenic
• Alliance: Disp1^em2Ogd page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutations: Insertion, Intragenic deletion, Nucleotide substitutions
• Mutation details: CRISPR/cas9-mediated recombination using guide RNAs targeting the extracellular loop 1 created multiple DNA changes resulting in a 3 amino acid substitution starting at position 278 of RRE to AAA. This mutation disrupts the Furin cleavage site in loop 1 compromising processing of the protein. (J:344557)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Disp1 Mutation: 61 strains or lines available

References

• Original: J:344557 Hall ET, et al., Cytoneme signaling provides essential contributions to mammalian tissue patterning. Cell. 2024 Jan 18;187(2):276-293.e23
• All: 1 reference(s)