Muc5b^em1Evns
Endonuclease-mediated Allele Detail

Summary

• Symbol: Muc5b^em1Evns
• Name: mucin 5, subtype B, tracheobronchial; endonuclease-mediated mutation 1, Christopher M Evans
• MGI ID: MGI:7578778
• Synonyms: Muc5b-EGFP
• Gene: Muc5b Location: Chr7:141392807-141426821 bp, + strand Genetic Position: Chr7, 87.29 cM, cytoband F5
• Alliance: Muc5b^em1Evns page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An EGFP gene was inserted into the third exon, before the first Cys encoding codon of the VWD1 domain, using CRISPR/Cas genome editing technology. (J:293471)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Muc5b Mutation: 215 strains or lines available

References

• Original: J:293471 Fakih D, et al., Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin. Am J Physiol Lung Cell Mol Physiol. 2020 Jun 1;318(6):L1270-L1279
• All: 1 reference(s)