Malt1^{tm1d(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Malt1^{tm1d(EUCOMM)Hmgu}
• Name: MALT1 paracaspase; targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:7571555
• Gene: Malt1 Location: Chr18:65564010-65612138 bp, + strand Genetic Position: Chr18, 38.56 cM
• Alliance: Malt1^{tm1d(EUCOMM)Hmgu} page
• IMPC: Malt1 gene page

Mutation origin

• Mutant Cell Line: HEPD0618_3_D10
• Germline Transmission: Earliest citation of germline transmission: J:333424
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 65577475 of Chromosome 18 upstream of the critical exon 3 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 3 at position 65578310. The critical exon 3 is thus flanked by loxP sites. The lacZ sequence and neo selection cassette were removed via flp-mediated recombination. The loxP-flanked critical exon 3 was removed via cre-mediated recombination generating a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:333424)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Malt1 Mutation: 33 strains or lines available

References

• Original: J:333424 O'Neill TJ, et al., TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease. Sci Immunol. 2021 Nov 12;6(65):eabh2095
• All: 2 reference(s)