Malt1^em2Krad
Endonuclease-mediated Allele Detail

Summary

• Symbol: Malt1^em2Krad
• Name: MALT1 paracaspase; endonuclease-mediated mutation 2, Daniel Krappmann
• MGI ID: MGI:7571554
• Synonyms: Malt1^TBMPM
• Gene: Malt1 Location: Chr18:65564010-65612138 bp, + strand Genetic Position: Chr18, 38.56 cM
• Alliance: Malt1^em2Krad page

Mutation origin

• Strain of Origin: (C57BL/6N x 129-Malt1^em1Krad)F1

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: CRISPR/Cas9 technology generated the paracaspase mutation, a TGT to GCG change resulting in a cysteine to alanine change at amino acid 472 (p.C472A) in exon 11, in zygotes carrying the Malt1^em1Krad allele. These mice thus carry the p.C472A mutation as well as p.E324A, p.E814A, and p.E803A. (J:333424)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Malt1 Mutation: 33 strains or lines available

References

• Original: J:333424 O'Neill TJ, et al., TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease. Sci Immunol. 2021 Nov 12;6(65):eabh2095
• All: 1 reference(s)