Gdf11^em1Rlee
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gdf11^em1Rlee
• Name: growth differentiation factor 11; endonuclease-mediated mutation 1, Richard T Lee
• MGI ID: MGI:7568815
• Synonyms: Gdf11^8aa, Gdf11^Gdf8aa
• Gene: Gdf11 Location: Chr10:128718164-128727587 bp, - strand Genetic Position: Chr10, 77.18 cM, cytoband D3
• Alliance: Gdf11^em1Rlee page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Aspartic acid codon 385 (GAC) in exon 3 was changed to glycine (GGC) (p.D385G) and glutamine codon 387 (CAG) to glutamic acid (GAG) (p.Q387E) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutations change the endogenous amino acids in the encoded peptide to their equivalents from paralog Mstn. (J:342779)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdf11 Mutation: 18 strains or lines available

References

• Original: J:342779 Lian J, et al., Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscle. Life Sci Alliance. 2023 Mar;6(3)
• All: 1 reference(s)