Zeb1^tm1.1Smoc
Targeted Allele Detail

Summary

• Symbol: Zeb1^tm1.1Smoc
• Name: zinc finger E-box binding homeobox 1; targeted mutation 1.1, Shanghai Model Organisms Center
• MGI ID: MGI:7562587
• Synonyms: Zeb1^fl
• Gene: Zeb1 Location: Chr18:5591860-5775467 bp, + strand Genetic Position: Chr18, 4.42 cM
• Alliance: Zeb1^tm1.1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:343049
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 4 was flanked by loxP sites and a FRT-flanked neomycin cassette was inserted downstream of exon 4 before the second loxP site. The neomycin cassette was removed via flp-mediated recombination. (J:343049)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zeb1 Mutation: 67 strains or lines available

References

• Original: J:343049 Wang Y, et al., The transcription factor Zeb1 controls homeostasis and function of type 1 conventional dendritic cells. Nat Commun. 2023 Oct 20;14(1):6639
• All: 1 reference(s)