Igs2^{em79(Vil1-Atp6ap2,-tdTomato)Gpt}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Igs2^{em79(Vil1-Atp6ap2,-tdTomato)Gpt}
• Name: intergenic site 2; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
• MGI ID: MGI:7562540
• Synonyms: ATP6AP2^KI
• Gene: Igs2 Location: Chr11:3195460-3195497 bp Genetic Position: Chr11, Syntenic
• Alliance: Igs2^{em79(Vil1-Atp6ap2,-tdTomato)Gpt} page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Epitope tag, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology inserted a construct consisting of the Villin-dependent promoter sequence, Atp6ap2 coding sequence, a Flag tag, P2A, TdTomato, and polyA into the locus. (J:340674)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igs2 Mutation: 72 strains or lines available

References

• Original: J:340674 Wang J, et al., (Pro)renin receptor promotes colorectal cancer progression through inhibiting the NEDD4L-mediated Wnt3 ubiquitination and modulating gut microbiota. Cell Commun Signal. 2023 Jan 3;21(1):2
• All: 1 reference(s)