Irs1^tm2Mfw
Targeted Allele Detail

Summary

• Symbol: Irs1^tm2Mfw
• Name: insulin receptor substrate 1; targeted mutation 2, Morris F White
• MGI ID: MGI:7562477
• Synonyms: Irs1 S302A
• Gene: Irs1 Location: Chr1:82210822-82269137 bp, - strand Genetic Position: Chr1, 42.0 cM, cytoband C5
• Alliance: Irs1^tm2Mfw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:342709
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Serine codon 302 (AGC) in exon 1 was changed to alanine (GCC) (p.S302A) through homologous recombination with a mutagenized cDNA. The mutation prevents phosphorylation of the residue in the encoded peptide. (J:342709)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irs1 Mutation: 55 strains or lines available

References

• Original: J:342709 Copps KD, et al., Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase. J Biol Chem. 2016 Apr 15;291(16):8602-17
• All: 1 reference(s)