Map4k4^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Map4k4^m1Btlr
• Name: mitogen-activated protein kinase kinase kinase kinase 4; mutation 1, Bruce Beutler
• MGI ID: MGI:7549174
• Synonyms: tank
• Gene: Map4k4 Location: Chr1:39940073-40065470 bp, + strand Genetic Position: Chr1, 18.53 cM, cytoband B
• Alliance: Map4k4^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Not Applicable)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced an undefined point mutation at GRCm38:chr1:40004864 that causes a missense mutation at glutamine codon (Q) 687 (CAG) (in ENSMUSP00000126961 and ENSMUSP00000141400; different coordinates in other isoforms) to either lysine (AAG) or glutamine (GAG). The mutation is implicated in altered T cell-dependent antibody responses to immunization. (J:217665)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map4k4 Mutation: 103 strains or lines available

References

• Original: J:217665 Wang T, et al., Real-time resolution of point mutations that cause phenovariance in mice. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E440-9
• All: 1 reference(s)