Muc5b^tm1.2Jzhe
Targeted Allele Detail

Summary

• Symbol: Muc5b^tm1.2Jzhe
• Name: mucin 5, subtype B, tracheobronchial; targeted mutation 1.2, Jinping Zheng
• MGI ID: MGI:7545267
• Gene: Muc5b Location: Chr7:141392807-141426821 bp, + strand Genetic Position: Chr7, 87.29 cM, cytoband F5
• Alliance: Muc5b^tm1.2Jzhe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:342039
• Parent Cell Line: JM8A3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked PGK-neo cassette and a loxP site were inserted upstream of exon 2 and a second loxP site was inserted downstream of exon 5. The neomycin cassette was removed via flp-mediated recombination. Exons 2-5 were deleted via cre-mediated recombination. (J:342039)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Muc5b Mutation: 215 strains or lines available

References

• Original: J:342039 Huang X, et al., MUC5B regulates goblet cell differentiation and reduces inflammation in a murine COPD model. Respir Res. 2022 Jan 18;23(1):11
• All: 1 reference(s)