Del(16Ifnar2-Ifngr2)1Jmes
Endonuclease-mediated Allele Detail

Summary

• Symbol: Del(16Ifnar2-Ifngr2)1Jmes
• Name: deletion, Chr 16, Joaquin M Espinosa 1
• MGI ID: MGI:7543063
• Synonyms: Ifnr^-
• Gene: Del(16Ifnar2-Ifngr2)1Jmes Location: unknown Genetic Position: Chr16, Syntenic

Mutation origin

• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intergenic deletion
• Del(16Ifnar2-Ifngr2)1Jmes involves 4 genes/genome features (Ifnar2, Il10rb, Ifnar1 ...) View all
• Mutation details: A 192 kb genomic segment encoding all four Ifnr genes, Ifnar2, Il10rb, Ifnar1, and Ifngr2, was deleted via CRISRP/Cas9 technology. Whole genome sequencing (WGS) confirmed the heterozygous deletion without other substantial genomic alterations. (J:337766)

Expression

In Mice Carrying this Mutation:

11 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(16Ifnar2-Ifngr2)1Jmes Mutation: 0 strains or lines available

References

• Original: J:337766 Waugh KA, et al., Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model. Nat Genet. 2023 Jun;55(6):1034-1047
• All: 1 reference(s)