Fendrr^em7Phg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fendrr^em7Phg
• Name: Foxf1 adjacent non-coding developmental regulatory RNA; endonuclease-mediated mutation 7, Phillip Grote
• MGI ID: MGI:7541333
• Synonyms: FendrrBox
• Gene: Fendrr Location: Chr8:121781621-121809849 bp, - strand Genetic Position: Chr8, 70.28 cM
• Alliance: Fendrr^em7Phg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:341586
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination using guide RNAs created a deletion including the 38bp UC-rich low complexity region in the second to last exon removing a site that binds target regions and tethering the lncRNA to the target gene. (J:341586)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fendrr Mutation: 0 strains or lines available

References

• Original: J:341586 Ali T, et al., Fendrr synergizes with Wnt signalling to regulate fibrosis related genes during lung development via its RNA:dsDNA triplex element. Nucleic Acids Res. 2023 Jul 7;51(12):6227-6237
• All: 1 reference(s)