Igs2^{em1(Adipoq-Mdm2)Xliu}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Igs2^{em1(Adipoq-Mdm2)Xliu}
• Name: intergenic site 2; endonuclease-mediated mutation 1, Xiaojun Liu
• MGI ID: MGI:7540641
• Synonyms: Mdm2-AKI
• Gene: Igs2 Location: Chr11:3195460-3195497 bp Genetic Position: Chr11, Syntenic
• Alliance: Igs2^{em1(Adipoq-Mdm2)Xliu} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence)
• Mutation: Insertion
• Igs2^{em1(Adipoq-Mdm2)Xliu} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mdm2 (MGI:96952)

• Mutation details: CRISPR/Cas9 technology inserted the murine Mdm2 coding sequence under the control of the adiponectin promotor into the docking site. (J:341509)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igs2 Mutation: 72 strains or lines available

References

• Original: J:341509 Zhao W, et al., Murine double minute 2 aggravates adipose tissue dysfunction through ubiquitin-mediated six-transmembrane epithelial antigen of prostate 4 degradation. iScience. 2022 Jul 15;25(7):104544
• All: 1 reference(s)